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| | Bis(trimethylsilyl)trifluoroacetamide Basic information | | Uses |
| Product Name: | Bis(trimethylsilyl)trifluoroacetamide | | Synonyms: | BSTFA containing 1% TMCS;N,O-Bis(trimethylsily)trifluoroamide;N,O-bis(trimethylsilyl)acetamide,*with 10%;N,O-Bis(trimethylsilyl)trifluoroacetamide, contains 10% TMCS;N,O-Bis(trimethylsilyl)trifluoroacetamide, contains 1% TMCS, ampuled under argon;Bis(trimethylsilyl)trifluoroacetamide for gas chromatography;Acetamide, 2,2,2-trifluoro-O,N-bis(trimethylsilyl)-;Ethanimidic acid, 2,2,2-trifluoro-N-(trimethylsilyl)-, trimethylsilyl ester | | CAS: | 25561-30-2 | | MF: | C8H18F3NOSi2 | | MW: | 257.4 | | EINECS: | 247-103-9 | | Product Categories: | Silylation Reagents;Blocking Agents;Analytical Chemistry;Protective Agents;Silazanes;Silylating Agents;Biochemistry;GC Derivatizing Reagents;Reagents for Oligosaccharide Synthesis;Si (Classes of Silicon Compounds);Silylacetamides;Silylation (GC Derivatizing Reagents);Si-N Compounds;Trimethylsilylation (GC Derivatizing Reagents);Silicon Compounds (for Synthesis);Synthetic Organic Chemistry | | Mol File: | 25561-30-2.mol |  |
| | Bis(trimethylsilyl)trifluoroacetamide Chemical Properties |
| Melting point | -10°C | | Boiling point | 45-50 °C14 mm Hg(lit.) | | density | 0.97 g/mL(lit.) | | refractive index | n20/D 1.384(lit.) | | Fp | 75 °C | | storage temp. | 2-8°C | | solubility | Miscible with chloroform. | | pka | 1.82±0.50(Predicted) | | form | Liquid | | color | Colorless to pale yellow | | Specific Gravity | 0.971 | | Water Solubility | hydrolyses | | Sensitive | Moisture Sensitive | | Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents | | BRN | 3607620 | | Stability: | Moisture Sensitive | | InChIKey | XCOBLONWWXQEBS-KPKJPENVSA-N | | CAS DataBase Reference | 25561-30-2(CAS DataBase Reference) | | NIST Chemistry Reference | Bis(trimethylsilyl)trifluoroacetamide(25561-30-2) |
| Hazard Codes | C,F,T | | Risk Statements | 11-34-10-35-14 | | Safety Statements | 26-36/37/39-45-16 | | RIDADR | UN 2924 3/PG 3 | | WGK Germany | 3 | | F | 10-21 | | Hazard Note | Flammable/Moisture Sensitive | | TSCA | Yes | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29310095 |
| | Bis(trimethylsilyl)trifluoroacetamide Usage And Synthesis |
| Uses | Used for synthesis of pharmaceutical intermediates.
| | Chemical Properties | Clear to yellowish clear liquid | | Uses | Used as a reactant in the preparation of pyrimidinone ribosides and analogs that show anti-tumor properties. | | Uses | N,O-bis(trimethylsilyl)-trifluoroacetamide (BSTFA) is similar to BSA in specificity of modification and there are several studies which have used both reagents.One study found BSTFA superior to BSA in product stability and yield of derivative. Another study compared several trimethylsilyl donors for end-capping of silica and observed that BSTFA was more reactive than BSA but less reactive than TMCim. Both BSA and BSTFA were used to prepare trimethylsilyl derivatives of pyrimidines and purines.Current work has used BSTFA for metabolomics analysis of urine,for the measurement of khatamines (psychoactive amines of khat (Catha edulis Forsk), and for the measurement of acrylamide in cocoa. | | Uses | N,O-Bis(trimethylsilyl)trifluoroacetamide is used for analytical purposes or as a chemical reagent for synthesis of more complex molecules. It is silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions. It is also used as DAT inhibitor and a SLC6A2 inhibitor. It is routinely used to derivatize carboxylic acids, phenols, steroids, amines, alcohols, and alkaloids and amides. | | Definition | ChEBI: A silyl ether that is the N,O-bis(trimethylsilyl) derivative of trifluoroacetamide. N,O-bis(trimethylsilyl)trifluoroacetamide is a derivatisation agent used in gas chromatography/m
ss spectrometry applications. | | General Description | N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane has found application to be used in gas chromatography (GC) and mass-spectrometry (MS). It can also be used in HPLC- electrochemical detection assay of 8-oxo-deoxyguanosine and?8-oxo-guanine. |
| | Bis(trimethylsilyl)trifluoroacetamide Preparation Products And Raw materials |
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