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Loratadine Impurity I

Loratadine Impurity I Basic information
Product Name:Loratadine Impurity I
Synonyms:Loratadine Impurity I;Loratadine USP RC I;Loratadine Impurity 30;Loratadine?Impurity?8/Dehydro?Loratadine?Isomer?B/Ethyl?4-(8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate;Loratadine Impurity 8/Dehydro Loratadine Isomer B;Desloratadine impurity K;Loratadine Impurity K;ethyl 4-(8-chloro-11H-benzo[5,6]cyclohepta
CAS:133330-56-0
MF:C22H21ClN2O2
MW:380.87
EINECS:
Product Categories:
Mol File:133330-56-0.mol
Loratadine Impurity I Structure
Loratadine Impurity I Chemical Properties
Boiling point 539.3±50.0 °C(Predicted)
density 1.283±0.06 g/cm3(Predicted)
solubility Chloroform (Slightly), Methanol (Slightly)
pka3.81±0.20(Predicted)
form Solid
color Off-White to Beige
Stability:Light Sensitive
Safety Information
MSDS Information
Loratadine Impurity I Usage And Synthesis
UsesEthyl 4-(8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate is an impurity of loratadine (L469575), which is a nonsedating-type histamine H1-receptor.
Loratadine Impurity I Preparation Products And Raw materials
Raw materials8-Chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one-->Loratadine
4-(8-Chloro-5,6-dihydro-3-hydroxy-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester Loratadine EP IMpurity F Loratadine N-Oxide Loratadine 2-Chloro IMpurity 8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol N-Carbethoxy-4-piperidone 3,5-Lutidine 4-Hydroxymethyl Loratadine (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride 4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-β]pyridin-11-one (Loratadine Impurity) 2-Hydroxymethyl Loratadine Loratadine EP Impurity E 8-Dechloro-9-chloro Loratadine 8-Dechloro-7-chloro Loratadine 4-chloro-loratadine N-Methyl Desloratadine Sch 37370 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile
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