2-Dimethylaminoethyl chloride hydrochloride

2-Dimethylaminoethyl chloride hydrochloride Basic information

Product Name:	2-Dimethylaminoethyl chloride hydrochloride
Synonyms:	N,N-Dimethylamino chloroethane hydrochloride;N,N-DIMETHYLAMINOETHYL CHLORIDE HYDROCHLORIDE;N,N-DIMETHYL-N-2-CHLOROETHYLAMMONIUM CHLORIDE;N-(2-CHLOROETHYL)-N,N-DIMETHYLAMMONIUM CHLORIDE;Chlorphenamine Impurity 5 HCl;2-chloro-n,n-dimethyl-ethanaminhydrochloride;2-chloro-n,n-dimethyl-ethylaminhydrochloride;N-(2-CHLOROETHYL)DIMETHYLAMINE HYDROCHLORIDE
CAS:	4584-46-7
MF:	C4H11Cl2N
MW:	144.04
EINECS:	224-970-1
Product Categories:	Intermediates;Halogen compounds;For Chlorpheniramine's Production
Mol File:	4584-46-7.mol

2-Dimethylaminoethyl chloride hydrochloride Chemical Properties

Melting point	201-204 °C(lit.)
storage temp.	Store below +30°C.
solubility	2000g/l
form	Crystalline Powder or Crystals
color	White to brown-yellow
Water Solubility	2000 g/L (20 ºC)
Sensitive	Hygroscopic
BRN	3591234
Stability:	Hygroscopic
InChIKey	LQLJZSJKRYTKTP-UHFFFAOYSA-N
CAS DataBase Reference	4584-46-7(CAS DataBase Reference)
EPA Substance Registry System	Ethanamine, 2-chloro-N,N-dimethyl-, hydrochloride (4584-46-7)

Safety Information

Hazard Codes	T,N,T+
Risk Statements	22-24-36/37/38-68-51/53-26
Safety Statements	26-36/37-45-61-36/37/39-28A
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	KQ9020000
Autoignition Temperature	220 °C
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29211980
Toxicity	LD50 orally in Rabbit: 238 mg/kg LD50 dermal Rabbit 290 mg/kg

MSDS Information

Provider	Language
2-chloroethyldimethylammonium chloride	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Dimethylaminoethyl chloride hydrochloride Usage And Synthesis

Appearance	2-Dimethylaminoethyl chloride hydrochloride is white to Off-White Solid
Applications	2-Chloro-N,N-dimethylethylamine is a widely used as an intermediate and starting reagent for organic synthesis.
Dangerous Goods Info	Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
Chemical Properties	Colorless to beige crystals
Uses	2-Chloro-N,N-dimethylethylamine hydrochloride (DMC) is used as intermediate for the synthesis of pharmaceuticals (e.g. bephenium hydroxnaphthoate, diltiazem, mepyramine and phenyltoloxamine). Product Data Sheet
Uses	2-Chloro-N,N-dimethylethylamine is a widely used as a intermediate and starting reagent for organic synthesis. Also acts as Intermediate for the syntheses of bephenium hydroxynaphthoate, diltiazem, mepyramine and phenyltoloxamine.
Definition	ChEBI: 2-dimethylaminoethyl chloride hydrochloride is a hydrochloride obtained by combining 2-dimethylaminoethyl chloride with one molar equivalent of hydrochloric acid. It is a hydrochloride and an organoammonium salt. It contains a 2-dimethylammonioethyl chloride.
Safety Profile	Poison by intraperitoneal and subcutaneous routes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx

2-Dimethylaminoethyl chloride hydrochloride Preparation Products And Raw materials

Raw materials	Thionyl chloride-->2-Dimethylaminoethanol-->Chloroacetic anhydride
Preparation Products	2-CHLORO-6-METHYLBENZALDEHYDE-->1-(2-DIMETHYLAMINOETHYL)PIPERAZINE-->4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE-->N'-BENZYL-N,N-DIMETHYLETHYLENEDIAMINE-->2-DIMETHYLAMINOETHANETHIOL HYDROCHLORIDE-->Bis[2-(dimethylamino)ethyl] persulfide-->Afimoxifene-->4-HYDROXYTAMOXIFEN-->Diltiazem-->dimethyl(2-phenoxyethyl)amine

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