ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Proline derivatives Boc-Hyp-OH

Boc-Hyp-OH

Boc-Hyp-OH Basic information
Product Name:Boc-Hyp-OH
Synonyms:(2S,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;(2S,4R)-N-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic Acid;Boc-(2S,4R)-4-Hydroxy-2-pyrrolidinecarboxylic Acid;N-ter;N-(tert-Butoxycarbonyl)-trans-4-hydroxy-L-proline ,98%;Boc-L-trans-hydroxyproline(Boc-trans-Hyp-OH) ,98.5%(HPLC);1,2-Pyrrolidinedicarboxylicacid,4-hydroxy-,1-(1,1-diMethylethyl)ester,(2S,4R)-;(2S)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid
CAS:13726-69-7
MF:C10H17NO5
MW:231.25
EINECS:604-011-7
Product Categories:Hydroxyproline [Hyp];Unusual Amino Acids;AMINOACIDS DERIVATIVES;Pyrrole&Pyrrolidine&Pyrroline;Amino Acids;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Boc-Amino acid series;1;bc0001
Mol File:13726-69-7.mol
Boc-Hyp-OH Structure
Boc-Hyp-OH Chemical Properties
Melting point 123-127 °C(lit.)
alpha -78 º (in H2O)
Boiling point 390.9±42.0 °C(Predicted)
density 1.312±0.06 g/cm3(Predicted)
refractive index -68 ° (C=1, MeOH)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka3.80±0.40(Predicted)
form Powder
color White to off-white
optical activity[α]20/D 53.5±2°, c = 1% in DMF
Water Solubility very faint turbidity
BRN 4295484
InChIKeyBENKAPCDIOILGV-RQJHMYQMSA-N
CAS DataBase Reference13726-69-7(CAS DataBase Reference)
EPA Substance Registry System(2S,4R)-1-tert-Butyl 4-hydroxy-1,2-pyrrolidinecarboxylate (13726-69-7)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HS Code 2933 99 80
HazardClass IRRITANT
MSDS Information
ProviderLanguage
SigmaAldrich English
Boc-Hyp-OH Usage And Synthesis
Chemical PropertiesWhite powder
UsesBoc-Hyp-OH is used in the preparation of hydroxyproline derivatives. It is an intermediate in the synthesis of Fosinopril-d5 Sodium Salt (F727803), the labeled analogue of Fosinopril Sodium Salt (F727800), a phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.
Biological ActivityBoc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
Boc-Hyp-OH Preparation Products And Raw materials
Preparation ProductsBOC-4-OXO-PRO-OME-->1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-4-methyl-, 1,1-dimethylethyl ester, (2S,4S)--->BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER-->N-BOC-cis-4-fluoro-L-proline-->H-Hyp(Bzl)-OH · HCl-->tert-butyl (S)-7-oxohexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate-->(2S,4R)-1-(tert-butoxycarbonyl)-4-((2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yl)oxy)pyrrolidine-2-carboxylicacid
(2S,4R)-4-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER (2S,4R)-1-(tert-butoxycarbonyl)-4-[2-chloro-5-(trifluoromethyl)phenoxy]pyrrolidine-2-carboxylic acid BOC-L-HYDROXYPROLINE METHYL ESTER,(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER,BOC-HYP-OME / BOC-L-HYDROXYPROLINE METHYL ESTER BOC-L-TRANSPRO(OTS)-OBN N-Boc-trans-4-tosyloxy-L-proline methyl ester 4-HYDROXY-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER 1-Boc-L-hydroxyproline ethyl ester (2S,4R)-1-(tert-butoxycarbonyl)-4-[2-fluoro-3-(trifluoromethyl)phenoxy]pyrrolidine-2-carboxylic acid (2S,4R)-BOC-4-(2-NAPHTHYLOXY)-PYRROLIDINE-2-CARBOXYLIC ACID BOC-L-HYDROXYPROLINE T-BUTYL ESTER (2S, 4R)-BOC-GAMMA-MSO-PROLINE METHYL ESTER Boc-Hyp-OH BOC-HYP(BZL)-OH BOC-HYP-OBZL (2S,4R)-1-(tert-butoxycarbonyl)-4-[2-chloro-3-(trifluoromethyl)phenoxy]pyrrolidine-2-carboxylic acid BOC-HYP-OH DCHA (2S,4R)-BOC-4-(2-NAPHTHYLMETHOXY)-PYRROLIDINE-2-CARBOXYLIC ACID 4-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
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