ChemicalBook Product Catalog Biochemical Engineering Inhibitors Metabolism PDE inhibitors S- (+)-Rolipram

S- (+)-Rolipram

S- (+)-Rolipram Basic information
Product Name:S- (+)-Rolipram
Synonyms:(S)-(+)-ROLIPRAM;(4S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one;Rolipram (S)-(+)-;(4S)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one;(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE;(+)-ROLIPRAM;(S)-ROLIPRAM;(4S)-4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone;(S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
CAS:85416-73-5
MF:C16H21NO3
MW:275.34
EINECS:
Product Categories:Signalling;Cyclic Nucleotide related;Inhibitors
Mol File:85416-73-5.mol
S- (+)-Rolipram Structure
S- (+)-Rolipram Chemical Properties
Melting point 133-136℃
density 1.155
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO : 100 mg/mL (363.19 mM; Need ultrasonic)
form White to off-white solid.
color White to Almost white
Safety Information
HS Code 2933.79.1500
MSDS Information
S- (+)-Rolipram Usage And Synthesis
UsesS-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer
UsesS-(+)-Rolipram is an inhibitor of cyclic AMP-specific phosphodiesterase. It is the S isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor
DefinitionChEBI: The (S)-enantiomer of rolipram.
Biological ActivityLess active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ).
storageRoom temperature
S- (+)-Rolipram Preparation Products And Raw materials
Raw materials3-CYCLOPENTYLOXY-4-METHOXYBENZALDEHYDE-->Bromocyclopentane-->Isovanillin
Preparation Products(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
RO 20-1724 ZARDAVERINE EHNA HYDROCHLORIDE CILOSTAMIDE (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Cilostazol 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE ZAPRINAST Vinpocetine BRL 50481 ETAZOLATE 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE AG 1295 Roflumilast 4-(3'-Methoxyphenyl)-2-pyrrolidinone 4-(4'-Methoxyphenyl)-2-pyrrolidinone S- (+)-Rolipram 1-(4-bromobenzyl)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
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