2-Aminopyrimidine

2-Aminopyrimidine Basic information

Product Name:	2-Aminopyrimidine
Synonyms:	PYRIMIDIN-2-AMINE;PYRIMIDIN-2-YLAMINE;TIMTEC-BB SBB004387;1,2-dihydro-2-imine-pyrimidin;2-amino-pyrimidin;2-pyridiylamine;2-Pyrimidinemine;pyrimidin-2-amine analogue
CAS:	109-12-6
MF:	C4H5N3
MW:	95.1
EINECS:	203-648-4
Product Categories:	Heterocyclic Building Blocks;Pyrimidines;PYRIMIDINE;FINE Chemical & INTERMEDIATES;APIs & Intermediate;Building Blocks;Amines;Nucleic acids;C4 to C5;Chemical Synthesis;109-12-6
Mol File:	109-12-6.mol

2-Aminopyrimidine Chemical Properties

Melting point	122-126 °C (lit.)
Boiling point	158 °C (139.5186 mmHg)
density	1.1031 (rough estimate)
refractive index	1.5200 (estimate)
Fp	103 °C
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Powder
pka	3.45(at 20℃)
color	White to light yellow
Water Solubility	SOLUBLE
BRN	107014
InChIKey	LJXQPZWIHJMPQQ-UHFFFAOYSA-N
CAS DataBase Reference	109-12-6(CAS DataBase Reference)
EPA Substance Registry System	2-Pyrimidinamine (109-12-6)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
RIDADR	UN 2811
WGK Germany	3
RTECS	UV6326000
F	8
TSCA	Yes
HS Code	29335995

MSDS Information

Provider	Language
2-Amino-1,3-diazine	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Aminopyrimidine Usage And Synthesis

Chemical Properties	white to light yellow powder
Uses	2-Aminopyrimidine is used in the synthesis of sulfonamides as isoform-selective inhibitors with efficacy in rodent pain models.
Definition	ChEBI: An aminopyrimidine carrying an amino group at position 2.
Synthesis Reference(s)	Tetrahedron Letters, 39, p. 1313, 1998 DOI: 10.1016/S0040-4039(97)10877-2
Purification Methods	Crystallise 2-aminopyrimidine from *C6H6, EtOH or H2O. [Beilstein 25 III/IV 2071.]

2-Aminopyrimidine Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->ZINC-->Guanidine hydrochloride-->Guanidine nitrate-->Mucochloric acid-->Zinc hydroxide-->DIETHOXYMETHANE-->6,7,8-Trifluoro-1,4-dihydrogen-4-oxo-quinoline-3-carboxylate ethyl ester-->propargyl aldehyde-->5-Chloropyrimidin-2-amine-->Carbamic acid, N-2-pyrimidinyl-, phenylmethyl ester-->2-Pyrimidinamine, 1-oxide (9CI)-->Isocytosine
Preparation Products	Buspirone-->5-BROMO-2-(DIMETHYLAMINO)PYRIMIDINE-->5-BROMO-2-(METHYLAMINO)PYRIMIDINE-->5-BROMO-2-FLUOROPYRIMIDINE-->Primisulfuron-methyl-->2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE-->2-Bromopyrimidine-->Nsc67301-->2-Pyrimidinamine, N-(1,3-benzodioxol-5-ylmethyl)-

Acetaminophen Aminopyrine 2-Amino-6-chloropurine-9-riboside ACETAMINOPHENOL BP/USP 2-Aminopurine 2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE EC 2.6.1.2 Sulfameter Sulfadiazine ALTRENOGEST 6-Aminocaproic acid Glycine 2-Aminopyrimidine Sulfamic acid 2-Aminophenol Tris(hydroxymethyl)aminomethane 4-AMINOPYRIMIDINE AMINO ACIDS

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