Isobutylmercaptan

Isobutylmercaptan Basic information

Product Name:	Isobutylmercaptan
Synonyms:	1-Isobutanethiol;1-Mercaptoisobutane;1-Propanethiol,2-methyl-;2-methyl-1-propanethio;2-methyl-1-propylmercaptan;Isobutanethiol;iso-Butanethiol;2-Methyl-3-propanethiol
CAS:	513-44-0
MF:	C4H10S
MW:	90.19
EINECS:	208-162-6
Product Categories:	Alkyl Thiols;Building Blocks;Chemical Synthesis;Contact Printing;Materials Science;Micro/NanoElectronics;Organic Building Blocks;Self Assembly &;Self-Assembly Materials;Sulfur Compounds;Thiols;Thiols/Mercaptans;thiol Flavor
Mol File:	513-44-0.mol

Isobutylmercaptan Chemical Properties

Melting point	-145°C
Boiling point	87-89 °C(lit.)
density	0.831 g/mL at 25 °C(lit.)
vapor density	3.1 (vs air)
vapor pressure	124 mm Hg ( 37.8 °C)
FEMA	3874 \| 2-METHYL-1-PROPANETHIOL
refractive index	n20/D 1.4385(lit.)
Fp	15 °F
solubility	H2O: slightly soluble
form	liquid
pka	10.41±0.10(Predicted)
color	Colorless to Light yellow
Odor	at 0.10 % in propylene glycol. cooked vegetable mustard
Odor Type	sulfurous
Odor Threshold	0.0000068ppm
JECFA Number	512
Merck	14,5147
BRN	1730890
LogP	2.18
CAS DataBase Reference	513-44-0(CAS DataBase Reference)
NIST Chemistry Reference	1-Propanethiol, 2-methyl-(513-44-0)
EPA Substance Registry System	1-Propanethiol, 2-methyl- (513-44-0)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

Isobutylmercaptan Usage And Synthesis

Chemical Properties	2-Methyl-1-propanethiol has a cooked vegetable, almost mustard-like, odor
Chemical Properties	Liquid; unpleasant odor.
Occurrence	Reported found in guava, milk, cooked beef, cooked pork and beer.
Uses	Flammable, dangerous fire risk.
General Description	2-methyl-1-propanethiol attaches with L-Cys (the carrier) via a disulfide bond to form the brain-targeted drug delivery systems (BTDS).
Purification Methods	Dissolve the thiol in EtOH, and add to 0.25M Pb(OAc)2 in 50% aqueous EtOH. The precipitated lead mercaptide is filtered off, washed with a little EtOH, and impurities are removed from the molten salt by steam distillation. After cooling, dilute HCl is added dropwise to the residue, and the mercaptan is distilled directly from the flask. Water is separated from the distillate, and the mercaptan is dried (Na2CO3) and distilled under nitrogen. [Mathias J Am Chem Soc 72 1897 1950, Beilstein 1 H 378, 1 I 191, 1 II 412, 1 III 1565, 1 IV 1605.]

Isobutylmercaptan Preparation Products And Raw materials

Raw materials	Thiourea-->1-Bromo-2-methylpropane
Preparation Products	2-Propanesulfinic acid,2-methyl--->Isobutanesulfonyl chloride-->Ethanamine, 2-[(2-methylpropyl)thio]-

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