(Bromomethyl)cyclobutane

(Bromomethyl)cyclobutane Basic information

Product Name:	(Bromomethyl)cyclobutane
Synonyms:	CYCLOBUTYLMETHYL BROMIDE;(BROMOMETHYL)CYCLOBUTANE;(Bromomethyl)codobutane;Cyclobutane, (bromomethyl)-;(BROMOMETHYL)CYCLOBUTANE 99%;(Bromomethyl)cyclobu;Cyclobuty-1-Methyl broMide;CYCLOBUTYL METHYL BROMIDE FOR SYNTHESIS
CAS:	17247-58-4
MF:	C5H9Br
MW:	149.03
EINECS:	700-027-4
Product Categories:	Cycloalkanes
Mol File:	17247-58-4.mol

(Bromomethyl)cyclobutane Chemical Properties

Boiling point	123-124 °C(lit.)
density	1.326 g/mL at 25 °C(lit.)
refractive index	n20/D 1.48(lit.)
Fp	97 °F
storage temp.	Inert atmosphere,2-8°C
form	Liquid
Specific Gravity	1.326
color	Clear colorless
Water Solubility	80mg/L at 20℃
InChIKey	FLHFTXCMKFVKRP-UHFFFAOYSA-N
CAS DataBase Reference	17247-58-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	10-36/37/38
Safety Statements	16-26-36
RIDADR	UN 1993 3/PG 3
WGK Germany	3
HazardClass	3
PackingGroup	III
HS Code	29038900

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English

(Bromomethyl)cyclobutane Usage And Synthesis

Chemical Properties	clear colorless liquid
Uses	(Bromomethyl)cyclobutane may be used in the synthesis of racemic 3-cyclobutylalanine and 17-(cyclobutylmethyl)morphinan-3-ol (butorphan).
Preparation	The preparation of (Bromomethyl)cyclobutane is as follows:Into a clean, dry reactor equipped with a stirrer and under nitrogen are successively loaded 5.4 kg of DMF (5.1 eqV) and then 4.53 kg of triphenylphosphite. 2.34 kg of bromine is then introduced while maintaining the temperature at less than 12°C. The stirring speed is regulated according to the fluidity of the reaction medium.10065] The set point of the jacket is then adjusted to -12°C. and then 1.120 kg of cyclobutylmethanol is introduced in such a way as not to exceed a temperature of -5° C. At the end of the addition the whole is allowed to return slowly to room temperature. After distillation and washing, the final product 2b (mass 1.529 kg) having a GC relative purity of 98.3% is obtained with a yield of 78%.
General Description	(Bromomethyl)cyclobutane (bromomethyl-cyclobutane) is an aryl fluorinated building block. Its reaction with various hydroxychromen-4-one derivatives in the presence of anhydrous K₂CO₃/dry acetone and Bu₄N⁺I^- (PTC) has been investigated.

(Bromomethyl)cyclobutane Preparation Products And Raw materials

Raw materials	Diethyl ether-->N,N-Dimethylformamide-->Government regulation-->Lithium Aluminum Hydride-->Triphenylphosphine-->Sodium ethoxide-->Boron trifluoride diethyl etherate-->1-Bromo-3-chloropropane-->CALCIUM HYDRIDE-->Cyclobutanemethanol-->Cyclobutanecarboxylic acid-->Diethyl 1,1-cyclobutanedicarboxylate
Preparation Products	nalbuphine-->Boceprevir-->5-CYCLOBUTYL-1,3-OXAZOL-2-AMINE

Cyclopropane 1-BROMO-4-CHLOROSPIRO(PENTACYCLO[4.3.0.0(2,5).0(3,8).0(4,7)]NONANE-9,2'-[1,3]-DIOXOLANE) Rocuronium bromide 1-Bromobutane 1-Bromo-2-methylpropane Octafluorocyclobutane (Bromomethyl)cyclobutane SPECS AE-534/30058013 Sodium bromate CYCLOBUTANE 4-Bromomethylbenzoic acid Benzyl bromide 2-BROMO-3-METHOXY-7,7-DIPHENYLBICYCLO[3.2.0]HEPTAN-6-ONE Ethidium bromide Allyl bromide SPECS AB-131/42302886 Methyl bromide 1,1-DIBROMO-SPIRO[2.3]HEXANE

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