5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate

5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate Basic information

Product Name:	5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate
Synonyms:	5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate;1-[BIS(DIMETHYLAMINO)METHYLEN]-5-CHLOROBENZOTRIAZOLIUM 3-OXIDE HEXAFLUOROPHOSPHATE;1-[BIS(DIMETHYLAMINO)METHYLENE]-5-CHLORO-1H-BENZOTRIAZOLIUM 3-OXIDE HEXAFLUOROPHOSPHATE;1-[BIS-(DIMETHYLAMINO)-METHYLENE]-5-CHLORO-1H-BENZOTRIAZOLIUM HEXAFLUOROPHOSPHATE 3-OXIDE;1-(BIS-DIMETHYLAMINO-METHYLENE)-5-CHLORO-3-OXY-1H-BENZOTRIAZOL-1-IUM HEXAFLUOROPHOSPHATE;2-(6-CHLORO-1-H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLAMINIUM HEXAFLUOROPHOSPHATE;1H-BENZOTRIAZOLIUM 1-[BIS(DIMETHYLAMINO)METHYLENE]-5CHLORO-,HEXAFLUOROPHOSPHATE (1-),3-OXIDE;2-(1H-6-CHLOROBENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYL-URONIUM HEXAFLUOROPHOSPHATE
CAS:	330645-87-9
MF:	C11H15ClF6N5OP
MW:	413.69
EINECS:	608-825-3
Product Categories:	Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);Biochemistry;Peptide Synthesis;Synthetic Organic Chemistry;Peptide;Peptide coupling agents;Peptide Coupling Reagents
Mol File:	330645-87-9.mol

5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate Chemical Properties

Melting point	185-190 °C
storage temp.	Store at +2°C to +8°C.
solubility	soluble in Dimethylformamide
form	powder to crystal
color	White to Almost white
InChIKey	ZHHGTMQHUWDEJF-UHFFFAOYSA-N
CAS DataBase Reference	330645-87-9(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate Usage And Synthesis

Chemical Properties	White powder
Uses	Reagent for: Synthesis of near-infrared pH activatable fluorescent probes Synthesis of human β-amyloid by Fmoc chemistry Stereoselective Horner-Wadsworth-Emmons olefination Covalent ligation of fluorescent peptides to quantum dots Alkylation of human telomere sequence
General Description	HCTU [1] is a novel aminium-based coupling reagent, analogous to HBTU, which in comparative studies was found to give superiort results to TBTU in the synthesis of difficult peptides [2], in hindered couplings [3], and cyclizations [4]. The product number for this product was previously 01-62-0038. To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate Preparation Products And Raw materials

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