ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Quinoline compounds 4-Hydroxy-2-methylquinoline

4-Hydroxy-2-methylquinoline

4-Hydroxy-2-methylquinoline Basic information
Product Name:4-Hydroxy-2-methylquinoline
Synonyms:TIMTEC-BB SBB003979;JR-8439, 4-Hydroxy-2-methylquinoline, 97%;2-METHYLQUINOLIN-4(1H)-ONE;2-METHYLQUINOLIN-4-OL;2-METHYL-4(1H)-QUINOLINONE;2-METHYL-4-QUINOLINOL;2-METHYL-4-HYDROXYQUINOLINE;AKOS 91415
CAS:607-67-0
MF:C10H9NO
MW:159.18
EINECS:210-140-6
Product Categories:Quinolines, Isoquinolines & Quinoxalines;Quinolines, Isoquinolines & Quinoxalines;Quinolines
Mol File:607-67-0.mol
4-Hydroxy-2-methylquinoline Structure
4-Hydroxy-2-methylquinoline Chemical Properties
Melting point 234-236 °C(lit.)
Boiling point 284.68°C (rough estimate)
density 1.1202 (rough estimate)
refractive index 1.6070 (estimate)
storage temp. Sealed in dry,Room Temperature
form powder to crystal
pka4.44±0.40(Predicted)
color White to Light yellow
Water Solubility Slightly soluble in water.
λmax317nm(CHCl3)(lit.)
BRN 118320
LogP1.902 (est)
CAS DataBase Reference607-67-0(CAS DataBase Reference)
NIST Chemistry Reference4-Quinolinol, 2-methyl-(607-67-0)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39-36/37/39-22
WGK Germany 3
HS Code 29334900
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
4-Hydroxy-2-methylquinoline Usage And Synthesis
Chemical PropertiesBEIGE POWDER
Uses4-Hydroxy-2-methylquinoline is act as an intermediate in the synthesis of dequalinium chloride and as pharmaceutical intermediate.
Uses4-Hydroxy-2-methylquinoline can be used as an intermediate in the synthesis of a wide range of medicinally important compounds such as:
  • Synthesis of 2-(quinolin-4-yloxy)acetamides as potent antitubercular agents.
  • Synthesis of 2-arylethenylquinoline derivatives for the treatment of Alzheimer′s disease.
  • Synthesis of 1,10-diethoxy-1H-pyrano[4,3-b]quinolones as antibacterial agents.
  • Synthesis of phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phophodiesterase 10A (PDE10A) inhibitors.

DefinitionChEBI: 2-Methyl-4-quinolinol is a member of quinolines.
4-Hydroxy-2-methylquinoline Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Dichloromethane-->PETROLEUM ETHER-->Aniline-->Diphenyl ether-->Methyl acetoacetate
Preparation Products4-CHLORO-2-METHYLQUINOLINE-->2-METHYL-QUINOLINE-4-THIOL
Methylparaben Methyl Isoquinoline Bensulfuron methyl Quinclorac Ethoxyquin 4-Hydroxy-2-methylquinoline Kresoxim-methyl 4-Cyanophenol Thiophanate-methyl QUINOLINE SULPHATE Quinaldine 8-Hydroxyquinoline Methyl acrylate 6-Hydroxy-2(1H)-3,4-dihydroquinolinone Methyl bromide CHLOROPHOSPHONAZO III Quinhydrone
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