ChemicalBook Product Catalog Organic Chemistry Hydrocarbons and derivatives Hydrocarbon nitrification 4-Methyl-3-nitrobenzoic acid methyl ester

4-Methyl-3-nitrobenzoic acid methyl ester

4-Methyl-3-nitrobenzoic acid methyl ester Basic information
Synthesis
Product Name:4-Methyl-3-nitrobenzoic acid methyl ester
Synonyms:4-METHYL-3-NITROBENZOIC ACID METHYL ESTER;METHYL 3-NITRO-4-METHYLBENZOATE;METHYL 4-METHYL-3-NITROBENZOATE;3-NITRO-P-TOLUIC ACID METHYL ESTER;RARECHEM AL BF 0233;4-Methyl-3-Nitro Benzoic Acid Methyl Ester Methyl 4-Methyl-3-Nitro Benzoate;3-NITRO-4-METHYLBENZOICACIDMETHYLESTER;BENZOICACID,4-METHYL-3-NITRO-,METHYLESTER(9CI)
CAS:7356-11-8
MF:C9H9NO4
MW:195.17
EINECS:230-886-6
Product Categories:Organic Building Blocks;Organic acids;Benzenes;Intermediates of Dyes and Pigments;Aromatic Esters;Building Blocks;C8 to C9;Carbonyl Compounds;Chemical Synthesis;Esters
Mol File:7356-11-8.mol
4-Methyl-3-nitrobenzoic acid methyl ester Structure
4-Methyl-3-nitrobenzoic acid methyl ester Chemical Properties
Melting point 49-53°C
Boiling point 298.0±20.0 °C(Predicted)
density 1?+-.0.06 g/cm3(Predicted)
Fp 110 °C
storage temp. Sealed in dry,Room Temperature
solubility Soluble in methanol.
form powder to crystal
color White to Light yellow
CAS DataBase Reference7356-11-8(CAS DataBase Reference)
EPA Substance Registry SystemBenzoic acid, 4-methyl-3-nitro-, methyl ester (7356-11-8)
Safety Information
Hazard Codes Xn
Risk Statements 22-43
Safety Statements 37/39
WGK Germany 2
TSCA Yes
HS Code 29163990
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
4-Methyl-3-nitrobenzoic acid methyl ester Usage And Synthesis
SynthesisMethyl 4-methyl-3-nitrobenzoate is synthesized by the following steps:Acid 33 (100 g, 0.552 mol) was dissolved in MeOH (1000 ml). Conc.  H2SO4 (30 ml) was added cautiously to this solution. The mixture was  refluxed for 8 hours. Solvent was distilled off. Ice-cold water was added  to the residue. It was then extracted with EtOAc, washed with NaHCO3 solution, water, dried (anhydrous Na2SO4), filtered and concentrated in  vacuo to furnish faint yellow a solid. (91.57 g).
Chemical PropertiesWhite solid
UsesMethyl 4-methyl-3-nitrobenzoate is used as pharmaceutical intermediate.
4-Methyl-3-nitrobenzoic acid methyl ester Preparation Products And Raw materials
Preparation ProductsIndole-6-carboxaldehyde-->1-TERT-BUTYL 6-METHYL 3-FORMYL-1H-INDOLE-1,6-DICARBOXYLATE-->6-HYDROXYMETHYLINDOLE-->Methyl 1H-indazole-6-carboxylate-->Methyl 3-amino-4-methylbenzoate-->3-Nitro-4-(2-oxo-propyl)-benzoic acid methyl ester
Methyl 2-methyl-3-nitrobenzoate 2-Methyl-3-Nitrobenzoic Acid Methyl Ester RARECHEM AL BI 0920 RARECHEM AL BD 0920 DECYL 9-(DICYANOMETHYLIDENE)-4,5,7-TRINITRO-9H-FLUORENE-2-CARBOXYLATE ETHYL 4-CYANO-3-NITROBENZOATE RARECHEM AL BK 0920 SPECS AG-690/09015049 2-NITRO-4-METHOXYCARBONYL BENZOIC ACID RARECHEM AL BZ 0898 4-METHYL-3,5-DINITRO METHYL BENZOATE RARECHEM AL BI 0233 METHYL 4-FORMYL-3-NITROBENZOATE 97 4-[(4-METHYL-BENZYLAMINO)-METHYL]-3-NITRO-BENZOIC ACID METHYL ESTER RARECHEM AL BM 0920 RARECHEM AL BP 0920 RARECHEM AL BL 0898 AURORA KA-6766
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