2-Thiophenemethylamine

2-Thiophenemethylamine Basic information
Product Name:2-Thiophenemethylamine
Synonyms:2-(AMINOMETHYL)THIOPHENE;1-THIEN-2-YLMETHANAMINE;2-(2-AMINOMETHYL)THIOPHENE;2-THIOPHENEMETHANAMINE;2-ThiophenMethylamine;Thiophene-2-methylamine,98+%;(THIOPHEN-2-YL)METHYLAMINE;2-methyl-3H-thiophen-2-amine
CAS:27757-85-3
MF:C5H7NS
MW:113.18
EINECS:248-639-6
Product Categories:Building Blocks;C4 to C6;Thiophens;Chemical Synthesis;Heterocyclic Building Blocks;Thiophenes;Thiophene&Benzothiophene;Electronic Chemicals
Mol File:27757-85-3.mol
2-Thiophenemethylamine Structure
2-Thiophenemethylamine Chemical Properties
Boiling point 95-99 °C/28 mmHg (lit.)
density 1.103 g/mL at 25 °C (lit.)
refractive index n20/D 1.5670(lit.)
Fp 165 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Easily soluble in ethanol and Chloroform.
pka8.95±0.29(Predicted)
form liquid
color Clear colorless to yellow
Sensitive Air Sensitive
BRN 106296
InChIKeyFKKJJPMGAWGYPN-UHFFFAOYSA-N
CAS DataBase Reference27757-85-3(CAS DataBase Reference)
NIST Chemistry Reference2-Thiophenemethanamine(27757-85-3)
EPA Substance Registry System2-Thiophenemethylamine (27757-85-3)
Safety Information
Hazard Codes C
Risk Statements 34
Safety Statements 26-27-36/37/39-45-25
RIDADR UN 3267 8/PG 2
WGK Germany 3
Hazard Note Corrosive
HazardClass 8
PackingGroup III
HS Code 29349990
MSDS Information
ProviderLanguage
2-(Aminomethyl)thiophene English
SigmaAldrich English
ACROS English
ALFA English
2-Thiophenemethylamine Usage And Synthesis
Chemical PropertiesClear yellow liquid
Uses2-Thiophenemethylamine can be used as areactant involved in synthesis of Triazole-linked-thiopene conjugates and a biomimetic model for studies of metal detoxification and oxidative stress involving metallothionein.
Uses2-Thiophenemethylamine is Reactant involved in synthesis of: Triazole-linked-thiopene conjugates. It is used for biomimetic model for studies of metal detoxification and oxidative stress involving metallothionein.It is a reactant involved in studies of organocatalyzed asymmetric reductive amination of ketones.
UsesReactant involved in synthesis of:
  • Triazole-linked-thiopene conjugates for use as a biomimetic model for studies of metal detoxification and oxidative stress involving metallothionein
  • Serotonin 5-HT1A receptor antagonists which have neuroprotective affects against ischemic cell damage
  • Imidazole- and piperonyl-containing thiadiazoles and pyrimidines for use as inducible oxide synthase dimerization inhibitors
  • Optoelectronic segmented polyurethanes

Reactant involved in:
  • Studies of organocatalyzed asymmetric reductive amination of ketones
  • Metal-free aerobic oxidative coupling of amines to imines
Synthesis Reference(s)Journal of the American Chemical Society, 68, p. 1389, 1946 DOI: 10.1021/ja01211a510
General Description2-Thiophenemethylamine is a potential ligand replacement for poly(3-hexylthiophene)/CdSe hybrid solar cells.
Purification MethodsDistil the amine under reduced pressure (nitrogen), from BaO, through a column packed with glass helices. The hydrochloride has m 193-194o (from EtOH/Me2CO) and the picrate has m 181-182o. [Beilstein 18 III/IV 7096.]
2-(Thien-2-yl)pyrrolidine METHAPYRILENE FUMARATE 2-Thiophenecarboxylic acid SILIBININ-N-METHYLGLUCAMINE, 95% (HPLC) 2-Thiophenecarboxylic acid hydrazide 2-THIOPHENECARBOXAMIDE Methylamine 5-[(BENZOYLAMINO)METHYL]THIOPHENE-2-SULFONYL CHLORIDE 2-Thiophenemethylamine Flunixin meglumine Thiophene trimethylamine oxide Trimethylamine Meglumine 5-CYANO-3,4-DIMETHYLTHIOPHENE-2-CARBOXAMIDE N,N-DIMETHYL-2-THIOPHENEMETHYLAMINE Cephalothin sodium N-(2-THIENYLMETHYL)UREA

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