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| | DIETHYLCARBAMAZINE CITRATE Basic information |
| | DIETHYLCARBAMAZINE CITRATE Chemical Properties |
| Melting point | 140 °C | | Boiling point | 516.39°C (rough estimate) | | density | 1.1718 (rough estimate) | | refractive index | 1.6500 (estimate) | | storage temp. | 2-8°C | | solubility | Very soluble in water, soluble in ethanol (96 per cent), practically insoluble in acetone. | | form | powder | | color | White to Almost white | | Water Solubility | almost transparency | | BRN | 3836352 | | BCS Class | 1 | | CAS DataBase Reference | 1642-54-2(CAS DataBase Reference) | | EPA Substance Registry System | Diethylcarbamazine citrate (1642-54-2) |
| | DIETHYLCARBAMAZINE CITRATE Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder, slightly hygroscopic. | | Originator | Hetrazan,Lederle,US,1949 | | Uses | Diethylcarbamazine Citrate can be used as an anthelmintic. The LD50 in rats is 1.38 g/kg. | | Definition | ChEBI: Diethylcarbamazine citrate is a piperazinecarboxamide. | | Manufacturing Process | To 50 cc of water was added 18 grams of 1-methylpiperazine dihydrochloride
and 8.34 grams of sodium hydroxide. When solution had been effected the
beaker was cooled to 10°C and with stirring, 4.17 grams of sodium hydroxide
dissolved in 15 cc of water and 14 grams of diethyl carbamyl chloride were
added simultaneously. When all had been added, the solution was extracted 3
times with ether which was then dried and filtered. The ether solution was
saturated with dry hydrogen chloride. A yellow gum appeared which on
trituration gave a white, hygroscopic solid which was filtered and dried in a
drying pistol. The N,N-diethyl-4-methyl-1-piperazine-carboxamide
hydrochloride had a melting point of 150°-155°C.
If the compound itself is desired, the salt is dissolved in water and the
solution saturated with a mild alkali such as potassium carbonate. The product
is then extracted with chloroform, dried, and after removal of the chloroform,
distilled.
| | Therapeutic Function | Anthelmintic | | General Description | Crystalline solid, scored white tablets. Used against filariasis in man and animals. | | Health Hazard | (Non-Specific -- Drugs, n.o.s.) May be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating or poisonous gases. Runoff from fire control or dilution water may cause pollution. The average adult man tolerates a single dose of 1.5 gm without ill effects. | | Fire Hazard | When heated to decomposition, DIETHYLCARBAMAZINE CITRATE emits toxic fumes of nitrogen oxides. Avoid decomposing heat. | | Safety Profile | Poison by inhalation
and intravenous routes. Moderately toxic by
ingestion, subcutaneous, and intraperitoneal
routes. An experimental teratogen. When
heated to decomposition it emits toxic
fumes of NOx. | | Veterinary Drugs and Treatments | Once the hallmark agent for heartworm disease prophylaxis in dogs,
DEC is no longer commercially available in the USA (in oral veterinary
dosage forms). DEC is approved for use for the prophylaxis of
heartworm
disease (D. immitis), and/or the treatment of ascariasis
in dogs. The drug is also used in ferrets and zoo animals susceptible
to heartworm. DEC is used in dogs at higher dosages as alternative
therapy
for several other parasites (see Dosage section below). Some
products were labeled for use in cats to treat ascarid infections.
In cats, DEC may help alleviate the course (preventing lymphoma
development) of FeLV infection.
In the U.K., DEC is used as an injectable product to control parasitic
bronchitis (Dictyocaulus viviparous) in sheep and cattle.
In humans, DEC is indicated as a filaricidal for the treatment
of Wucheria bancrofti, Brugia malayi, Loa loa, and Onchocerca
volvulus. |
| | DIETHYLCARBAMAZINE CITRATE Preparation Products And Raw materials |
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