3,4-Dihydro-7-hydroxy-2(1H)-quinolinone

3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Basic information
Description
Product Name:3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
Synonyms:7-Hydroxy-3,4-dihydro-2(1H)-quinolinone;Aripiprazole Dihydroquinolinone Impurity (USP);7-Hydroxy-3,4-dihydro-2(1H)-chinolinon;Intermediate of Aripiprazole;Aripiprazole Impurity 13;7- hydroxy-3,4- twohydrogen -2(1H)- quinolinone;7-Hydroxy-3,4-dihydro-2(H)-quinolinone;3,4-Dihydro-7-hydroxy-2(1H)-quinolinone SynonyMs 7-Hydroxy Carbostyril
CAS:22246-18-0
MF:C9H9NO2
MW:163.17
EINECS:239-784-6
Product Categories:Heterocycles;Quinoline derivatives;INTERMEDIATESOFARIPIPRAZOLE;Intermediates of Aripiprazole;Aromatics;Intermediates & Fine Chemicals;Quinolines, Quinazolines and derivatives;Aromatics Compounds;Pharmaceuticals;22246-18-0
Mol File:22246-18-0.mol
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Structure
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Chemical Properties
Melting point 233-237 °C
Boiling point 403.7±45.0 °C(Predicted)
density 1.282±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka9.60±0.20(Predicted)
color Pale Yellow
InChIKeyLKLSFDWYIBUGNT-UHFFFAOYSA-N
CAS DataBase Reference22246-18-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-43
Safety Statements 36/37
WGK Germany 3
HS Code 29334900
MSDS Information
ProviderLanguage
SigmaAldrich English
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Usage And Synthesis
Description3,4-Dihydro-7-hydroxy-2 (1H)-quinolinone is a useful organic and pharmaceutical intermediate. It can be used as the precursor of aripiprazole1, which is an antipsychotic medication. It is also an antitumor agent and hydroxyindole analog inhibitor tyrosinase melanoma.
Chemical PropertiesPale Yellow Powder
Uses3,4-Dihydro-7-hydroxyquinoline-2(1H)-one (Aripiprazole EP Impurity A) is an antitumor agent. Hydroxyindole analog inhibitor tyrosinase melanoma. This compound is also used in the preparation of aripiprazole (A771000).
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Preparation Products And Raw materials
Preparation Products7-Methoxy-3,4-dihydro-1H-quinolin-2-one-->3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone-->6-Bromo-7-ethoxy-1,2,3,4-tetrahydroquinolin-2-one-->7-(Benzyloxy)-3,4-dihydrocarbostyril-->7-(4-BroMobutoxy)-3,4-dihydroquinolin-2-one-d8
Dehydroepiandrosterone 6-HYDROXY-7-METHOXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE AURORA KA-3562 AURORA KA-3683 AURORA KA-4645 Tetrahydro-4H-pyran-4-one AURORA KA-4062 AURORA KA-4058 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone 2-Quinolinol 3,4-Dihydro-7-hydroxy-1-(2-piperidinopropyl)carbostyril 4'-Hydroxyacetophenone 1-Tetralone 2'-Hydroxyacetophenone 8-Hydroxyquinoline CHLOROPHOSPHONAZO III Quinhydrone AURORA KA-3198

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