| Uses | 3-Nitrophthalic Acid is a useful chemical in organic synthesis. It is also an impurity of Apremilast. |
| Chemical Properties | pale yellow crystals |
| Uses | 3-Nitrophthalic acid may be used as starting reagent in the synthesis of modified 2-iodoxybenzoic acid derivatives. It may be used in the synthesis of brucinium 2-carboxy-6-nitrophthalate dihydrate (systematic name: 2,3-dimethoxy-10-oxostrychnidinium 2-carboxy-6-nitrophthalate dihydrate), via heating with brucine. |
| Uses | 3-Nitrophthalic Acid is a useful chemical in organic synthesis. It is also an impurity of Apremilast. |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 39, p. 2468, 1974 DOI: 10.1021/jo00930a051 |
| General Description | 3-Nitrophthalic acid is a degradation product of isoxaben herbicide. It acts as ligand and forms rare-earth complexes. |
| Safety Profile | A preparative hazard. When heated to decomposition it emits toxic fumes of NOx. |
| Purification Methods | Crystallise 3-nitrophthalic acid from hot water (1.5mL/g). Dry it in air. The amide has m 201o (from EtOH). [Beilstein 9 H 823, 9 IV 3275.] |
