|
| | Benidipine hydrochloride Basic information |
| Product Name: | Benidipine hydrochloride | | Synonyms: | (R,R)-(+/-)-2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDRO-3,5-PYRIDINE,DICARBOXYLIC ACID METHYL-1-BENZYL-3-PIPERIDYL-ESTER,MONOHYDROCHLORIDE SALT;Coniel, Capadipine, KW-3049, Nacadipine;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (4R)-rel-;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (R*,R*)-(+-)-;(R,R)-(+/-)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-Dihydro-3,5-pyridine-dicarboxylic acid methyl-1-benzyl-3-piperidyl-ester hydrochloride;Benidipine hydrochloride;monohydrochloride,(r*,r*)-(+-)-hyl1-(phenylmethyl)-3-piperidinyleste;1-(BENZYLMETHYL)-3-PIPERIDINYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOLATE | | CAS: | 91599-74-5 | | MF: | C28H31N3O6 | | MW: | 505.56 | | EINECS: | 663-500-3 | | Product Categories: | Inhibitors;Antihypertensive;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Chiral Reagents;Heterocycles | | Mol File: | 91599-74-5.mol |  |
| | Benidipine hydrochloride Chemical Properties |
| Melting point | 199-201°C | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO: ≥20mg/mL | | pka | 7.34(at 25℃) | | form | powder | | color | yellow | | InChIKey | DGVVISBYHUXFIU-UHFFFAOYSA-N | | CAS DataBase Reference | 91599-74-5(CAS DataBase Reference) |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | RTECS | US7975657 | | HS Code | 2933.99.5300 | | Toxicity | LD50 orally in male mice: 218 mg/kg (Muto, 1988) |
| | Benidipine hydrochloride Usage And Synthesis |
| Description | Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals,
benidipine hydrochloride dose dependently induced hypotension with a potency of
6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a
slow onset of action. | | Description | Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels. In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology. It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury. Benidipine is also a competitive antagonist at mineralocorticoid receptors. | | Chemical Properties | Yellow Crystalline Powder | | Originator | Kyowa Hakko (Japan) | | Uses | A dihydropyridine calcium channel blocker. Antihypertensive. | | Brand name | Coniel | | Biological Activity | Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo . Inhibits L-, N- and T-type Ca 2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects. | | Safety Profile | A poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic vapors of NOx and HCl. | | storage | room temperature (desiccate) |
| | Benidipine hydrochloride Preparation Products And Raw materials |
|
