(E)-2-oxopropanal oxime

(E)-2-oxopropanal oxime Basic information
Product Name:(E)-2-oxopropanal oxime
Synonyms:ANTI-PYRUVIC ALDEHYDE 1-OXIME;ISONITROSOACETONE;2-oxopropionaldehyde 1-oxime;PYRUVALDEHYDE 1-OXIME 98+%;2-OXO-PROPIONALDEHYDE OXIME;Propanal, 2-oxo-, 1-oxime;1-(Hydroxyimino)acetone;1-Hydroxyimino-2-propanone
CAS:306-44-5
MF:C3H5NO2
MW:87.08
EINECS:206-184-0
Product Categories:
Mol File:306-44-5.mol
(E)-2-oxopropanal oxime Structure
(E)-2-oxopropanal oxime Chemical Properties
Melting point 69°
Boiling point 160.87°C (rough estimate)
density 1.0744
refractive index 1.4940 (estimate)
solubility Chloroform (Slightly), Methanol (Slightly)
pkapK (25°) 8.39
form Solid
color Brown
EPA Substance Registry SystemPropanal, 2-oxo-, 1-oxime (306-44-5)
Safety Information
MSDS Information
(E)-2-oxopropanal oxime Usage And Synthesis
Uses(E)-2-oxopropanal oxime can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and pharmaceutical and chemical production processes.
PreparationTo a well-stirred, ice-cooled solution of 5.8 gm (0.1 mole) of acetone in 30 ml of glacial acetic acid is added dropwise a concentrated aqueous solution containing 15 gm of sodium nitrite. Stirring at 0°C is continued for 45 min, then 100 ml of water is added and the crude product is extracted with ether.
306-44-5 synthesis
The ether extracts are combined, washed repeatedly with 10 ml portions of water, and dried with sodium sulfate. The ether is evaporated off under reduced pressure and the residue is dried on a porous plate. After recrys-tallization from benzene, 6 gm (69%) of the product is isolated, m.p. 65°C.

Synthesis3.png
under the condition of the ice, to 1000 ml three port successively added in the bottle KOH (58.35g, 1 . 16eq, 1 . 04mol) and 585 ml water, the reaction system is cooled to 0 °C, adding to the reaction system (103.61g, 1eq, 0.892mol), after stirring at room temperature add 24h; once again the reaction system is cooled to 0 °C, in the reaction system by adding NaNO2(71.76g, 1 . 16eq, 1 . 04mol), the reaction system to maintain 0 °C, to wherein the dropwise H2SO4(50%), the for PH 4-5 (adding sulphuric acid to the volume to the final system is PH), stir at room temperature 2h, this will produce a large amount of gas in the process, a white precipitate, then in to the system by adding NaOH (35%) solution, the for PH 9-10, finally in the reaction system by adding 100 ml of toluene, the organic phase and aqueous phase separation, is added to the aqueous phase H2SO4(50%) the adjusted to PH 5-6, ethyl acetate (3*100 ml) extraction, anhydrous sodium sulfate for drying, can be obtained turns on lathe does white solid 61 . 3g (yield 79%).
(E)-2-oxopropanal oxime Preparation Products And Raw materials
Preparation Products3-Acetyl-2,4-dimethylpyrrole
pentane-2,3-dione 2-oxime 1-PHENYL-1,2,3-BUTANETRIONE 2-OXIME 1-Phenyl-1,2-propanedione-2-oxime ETHYL 2-([(2,4-DICHLOROBENZYL)OXY]IMINO)-3-OXOBUTANOATE 1-[5-(([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)METHYL)-4,5-DIHYDRO-3-ISOXAZOLYL]-3-(4-METHOXYANILINO)-2-PROPEN-1-ONE 1-[5-(([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)METHYL)-4,5-DIHYDRO-3-ISOXAZOLYL]-3-[4-(TRIFLUOROMETHOXY)ANILINO]-2-PROPEN-1-ONE 4-CHLOROPHENYLGLYOXYLOHYDROXAMYL CHLORIDE (E)-2-oxopropanal oxime (1S,E)-(-)-Camphorquinone 3-oxime (4-METHYLPHENYL)(OXO)ACETALDEHYDE OXIME (4-BROMO-PHENYL)-OXO-ACETALDEHYDE OXIME ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE 1-[5-(([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)METHYL)-4,5-DIHYDRO-3-ISOXAZOLYL]-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE 2-Isonitrosoacetophenone 2-OXO-2-(3-PYRIDYL)ACETALDEHYDE OXIME 2-hydroxyimino-1-(4-methoxyphenyl)ethanone 2-[[(ETHOXYCARBONYL)OXY]IMINO]-1,2-DIPHENYLETHAN-1-ONE 1-(4-Chlorophenyl)-2-(hydroxyimino)ethanone

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