ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyrimidines Methoxy-pyrimidine 4-Amino-6-methoxypyrimidine

4-Amino-6-methoxypyrimidine

4-Amino-6-methoxypyrimidine Basic information
Product Name:4-Amino-6-methoxypyrimidine
Synonyms:TIMTEC-BB SBB004268;4-AMINO-6-METHOXYPYRIMIDINE;6-METHOXYPYRIMIDIN-4-AMINE;6-METHOXY-PYRIMIDIN-4-YLAMINE;6-METHOXY-4-PYRIMIDINAMINE;4-Pyrimidinamine, 6-methoxy- (9CI);6-Methoxypyrimidine-4-amine;4-Amino-6-methyloxypyrimidine
CAS:696-45-7
MF:C5H7N3O
MW:125.13
EINECS:626-150-2
Product Categories:Heterocycle-Pyrimidine series;Building Blocks;PYRIMIDINE;Amines;Heterocyclic Building Blocks;Pyrimidines;Pyrazines, Pyrimidines & Pyridazines;Imidazoles & Benzimidazoles
Mol File:696-45-7.mol
4-Amino-6-methoxypyrimidine Structure
4-Amino-6-methoxypyrimidine Chemical Properties
Melting point 157-160 °C (lit.)
Boiling point 232.57°C (rough estimate)
density 1.2602 (rough estimate)
refractive index 1.6190 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO, Methanol
pka4.11±0.10(Predicted)
form Crystalline Powder
color White to yellow
InChIKeyVELRBZDRGTVGGT-UHFFFAOYSA-N
CAS DataBase Reference696-45-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-21/22-6/37/38
Safety Statements 26-36-36/37/39
WGK Germany 3
HazardClass IRRITANT
HS Code 29335990
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
4-Amino-6-methoxypyrimidine Usage And Synthesis
Chemical PropertiesWhite to yellow powder.
Uses6-Methoxy-4-pyrimidinamine is used in the synthesis of carbamothiolacrylamides as selective EP2 antagonists in the treatment of neurodegenerative peripheral diseases. Also used in the preparation of PARP-1 inhibitors.
Synthesis Reference(s)Journal of Heterocyclic Chemistry, 15, p. 1121, 1978 DOI: 10.1002/jhet.5570150710
4-Amino-6-methoxypyrimidine Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Methanol-->Phosphorus oxychloride-->Nitrogen-->Formamide-->Trichloroethylene-->4-Amino-6-chloropyrimidine
sulfametomidine PYRIMIDINE, 4-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-6-(4-PROPYLPHENOXY)- (E)-N-(2,6-DIMETHOXYPYRIMIDIN-4-YL)-4-((1-METHYL-2-OXOINDOLIN-3-YLIDENE)METHYLAMINO)BENZENESULFONAMIDE Bosentan SALOR-INT L345393-1EA Sulfadimethoxine sodium salt CHEMBRDG-BB 5339663 4-(Acetylamino)-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide PYRIMIDINE, 4-([1,1'-BIPHENYL]-4-YLOXY)-6-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)- 4-Amino-6-methoxypyrimidine PYRIMIDINE, 4-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-6-METHOXY-2-PHENYL- ETHANONE, 1-[4-[[6-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-4-PYRIMIDINYL]OXY]PHENYL]- 4-Amino-2,6-dimethoxypyrimidine Sulfadoxine BENZONITRILE, 4-[[6-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-4-PYRIMIDINYL]OXY]- 4-AMINO-6-METHOXY-2-METHYLPYRIMIDINE-5-CARBONITRILE Sulfamonomethoxine PYRIMIDINE, 4-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-6-PHENOXY-
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