(1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol

(1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol Basic information
Product Name:(1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol
Synonyms:(1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol;(1R)-2-({6-[(2-{[(2,6-dichlorophenyl)methyl]oxy}ethyl)oxy]-hexyl}amino)-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol;Vilanterol Impurity 1;Vilanterol Impurity;4H-1,3-Benzodioxin-6-methanol, α-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]amino]methyl]-2,2-dimethyl-, (αR)-;(1R) -2- [6- [2- [(2,6-dichlorobenzyl) oxy] ethoxy] hexyl] amino] -1- (2,2-dimethyl-4H-1,3-benzodioxane 6-yl) ethanol
CAS:503068-37-9
MF:C27H37Cl2NO5
MW:526.49
EINECS:
Product Categories:Intermediate
Mol File:503068-37-9.mol
(1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol Structure
(1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol Chemical Properties
Boiling point 637.3±55.0 °C(Predicted)
density 1.189±0.06 g/cm3(Predicted)
pka13.99±0.20(Predicted)
Safety Information
MSDS Information
(1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol Usage And Synthesis
Uses(1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]amino]-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol is an impurity of Vilanterol (V260000, Trifenatate), a long-acting β2 adrenergic receptor Agonist. It demonstrates prolonged bronchodilation in subjects with asthma and COPD.
(1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol Preparation Products And Raw materials
Preparation ProductsVilanterol Trifenatate-->Vilanterol Acetate
Vilanterol Impurity 14 Vilanterol Impurity 6 Triphenylacetate Vilanterol Impurity 25 Vilanterol Trifenatate Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Benzaldehyde, 5-[(1R)-2-[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]amino]-1-hydroxyethyl]-2-hydroxy- Vilanterol Impurity 7 Triphenylacetate Vilanterol Impurity 23 5-(2,2-diMethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one Vilanterol Impurity 3 Triphenylacetate Carbamic acid, N-[2-(2,2-dimethyl-4H-1,3-benzodioxin-5-yl)-2-oxoethyl]-, 1,1-dimethylethyl ester

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