ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate

rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate

rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate Basic information
Product Name:rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate
Synonyms:rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate;Tiotropium EP Impurity D;2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-6-en-3-yl ester;Tiotropium Bromide EP Impurity D;(1R,3S,5S)-2'-hydroxy-2',2'-di(thiophen-2''-yl)acetic acid 8-methyl-8-azabicyclo[3.2.1]oct-6-en-3-yl ester;Tiotropium Bromide Impurity 4(Tiotropium Bromide EP Impurity D)
CAS:136310-66-2
MF:C18H19NO3S2
MW:361.47
EINECS:
Product Categories:Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Mol File:136310-66-2.mol
rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate Structure
rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate Chemical Properties
Boiling point 522.8±50.0 °C(Predicted)
density 1.39±0.1 g/cm3(Predicted)
solubility DMSO (Slightly, Heated), Methanol (Slightly)
pka10.33±0.29(Predicted)
form Solid
color Pale Orange to Brown
Stability:Hygroscopic
Safety Information
MSDS Information
rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate Usage And Synthesis
Uses(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-ylacetate is an impurity in the synthesis of Tiotropium Bromide (T444850), a muscarinic receptor antagonist. Bronchodilator.
rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate Preparation Products And Raw materials
Methyl 2,2-dithienylglycolate 4-(4-Piperidyl)-1-butanol BIS(2-THIENYL) KETONE Tiotropium bromide Impurity 16 (1α,2β,4β,5α)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7α-ol Teloidine Ethanedioic acid,1-methyl ester, potassium salt (1:1) TiotropiuM BroMide IMpurity I 2-HYDROXY-2,2-BIS(2-THIENYL) ACETIC ACID N,N-dimethyl-4-methoxyphenylethylamine Scopine Methobromide Tiotropium EP Impurity C N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine 1197-11-8 Tiotropium-D6 Bromide DesvancosaMinyl VancoMycin Torsemide Related Compound 1 trans-trans-4,4'-iminodimethylenedi(cyclohexanecarboxylic acid)
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