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| | BroMosporine Basic information |
| Product Name: | BroMosporine | | Synonyms: | BroMosporine;ethyl 3-Methyl-6-(4-Methyl-3-(MethylsulfonaMido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-ylcarbaMate;N-[6-(3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate;CS-921;Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester;BroMosporine USP/EP/BP;11,Bromosporine,inhibit,AML,colorectal cancer,CDK,antitumor,T cells,HCT116,Apoptosis,HT29,anticancer,Epigenetic Reader Domain,Inhibitor,Cyclin dependent kinase;KASUMI-1,HIV,AIDS,Human immunodeficiency virus,MV4 | | CAS: | 1619994-69-2 | | MF: | C17H20N6O4S | | MW: | 404.44 | | EINECS: | | | Product Categories: | Inhibitors;API | | Mol File: | 1619994-69-2.mol |  |
| | BroMosporine Chemical Properties |
| density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Soluble in DMSO (up to 25 mg/ml) | | form | solid | | pka | 6.21±0.46(Predicted) | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | BroMosporine Usage And Synthesis |
| Description | Bromosporine (1619994-69-2) is a potent pan-Bromodomain (BRD) inhibitor.1?Bromosporine was able to reactivate HIV-1 replication in different latency models.2 | | Uses | Bromosporine is a broad spectrum inhibitor for bromodomains. | | target | bromodomain | | storage | Store at +4°C | | References | 1) Picaud?et al.?(2016),?Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia; Sci. Adv.?2?e1600760
2) Pan?et al.?(2017),?The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells; Oncotarget?8?94104 |
| | BroMosporine Preparation Products And Raw materials |
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