ChemicalBook Product Catalog Biochemical Engineering Inhibitors Cell Cycle CDK inhibitors ML167

ML167

ML167 Basic information
Product Name:ML167
Synonyms:ML167;ML167/ML-167;5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol;CID 44968231;5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol ML167;NCGC00188654;(5-(4-(((5-Methylfuran-2-yl)methyl)amino)quinazolin-6-yl)furan-2-yl)methanol;CID44968231;NCGC00188654
CAS:1285702-20-6
MF:C19H17N3O3
MW:335.36
EINECS:808-432-9
Product Categories:Inhibitors
Mol File:1285702-20-6.mol
ML167 Structure
ML167 Chemical Properties
Boiling point 531.8±45.0 °C(Predicted)
density 1.335±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble10mg/mL, clear
pka13.84±0.10(Predicted)
form powder
color off-white to gray to brown
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 46
WGK Germany 3
MSDS Information
ML167 Usage And Synthesis
DescriptionML167 (1285702-20-6) is a highly selective cell permeable inhibitor of Cdc2-like kinase 4 (Clk4) – IC50?= 136nM. It displays at least 10-fold greater selectivity over the related kinases Clk1(1.52 μM), Clk2(1.65μM), Clk3(>10μM), Dyrk1A(>10μM), and Dyrk1B(4.4 μM).
DefinitionChEBI: [5-[4-[(5-methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanol is a member of quinazolines.
targetClk4
References1) Rosenthal?et al. (2010),?An inhibitor of the Cdc2-like kinase 4 (Clk4); Probe Reports from the NIH Molecular Libraries Program
ML167 Preparation Products And Raw materials
GW5074 ZM 306416 hydrochloride 6,7-Dimethoxy-N-(4-phenoxyphenyl)- AZ191 Tenovin-6 STO-609 (acetate) TG003 GSK2656157 Sorafenib tosylate PP242
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