4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Basic information
Product Name:4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
Synonyms:BenzenaMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]-;[4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl]amine;4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline;6,7-Dimethoxy-4-(4-aminophenoxy)quinoline;BenzeMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]-;4-[(6,7-diMethoxy-4-quinolinyl)oxy]-BenzenaMine;4-(2,3-dimethoxynaphthalen-5-yloxy)benzenamine;4-[(6,7-dimethoxy-4-quinolinyl)oxy]-
CAS:190728-25-7
MF:C17H16N2O3
MW:296.32
EINECS:
Product Categories:
Mol File:190728-25-7.mol
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Structure
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Chemical Properties
Melting point 211.0 to 215.0 °C
Boiling point 481.8±45.0 °C(Predicted)
density 1.246±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly, Sonicated), Methanol (Slightly)
form powder to crystal
pka6.79±0.30(Predicted)
color Light yellow to Brown
InChIInChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-8-7-15(13)22-12-5-3-11(18)4-6-12/h3-10H,18H2,1-2H3
InChIKeyVXEQRXJATQUJSN-UHFFFAOYSA-N
SMILESC1(N)=CC=C(OC2C3C(N=CC=2)=CC(OC)=C(OC)C=3)C=C1
Safety Information
HS Code 2933.49.7000
MSDS Information
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Usage And Synthesis
Uses4-(6,7-Dimethoxy-Quinolin-4-Yloxy)-Phenylamine is used in preparation of Cabozantinib Defluorination impurity.
Chemical Reactivity4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline is a primary alcohol that has been shown to catalyze the reaction of potassium carbonate with an alkali metal hydroxide to produce potassium. It has also been shown to be a base catalyst for the reaction of cyclopropanecarboxylic acid with an alcohol ester to produce high yield.
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Preparation Products And Raw materials
Preparation ProductsCabozantinib
Cabozantinib Malate 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid

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