|
| | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Basic information |
| | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Chemical Properties |
| Melting point | 133 °C | | Boiling point | 370.6±32.0 °C(Predicted) | | density | 1.270±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 14.77±0.50(Predicted) | | color | Light Brown to Brown | | Stability: | Hygroscopic | | InChI | InChI=1S/C11H8FNO/c12-10-4-2-1-3-9(10)11-5-8(7-14)6-13-11/h1-7,13H | | InChIKey | MQULPEUCGKEHEG-UHFFFAOYSA-N | | SMILES | N1C(C2=CC=CC=C2F)=CC(C=O)=C1 |
| | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Usage And Synthesis |
| Chemical Properties | Light orange to Yellow to Green powder to crystal. | | Uses | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB). | | Application | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc. | | Preparation | Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%. |
| | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Preparation Products And Raw materials |
|
