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| | Skepinone-L Basic information |
| Product Name: | Skepinone-L | | Synonyms: | 5H-Dibenzo[a,d]cyclohepten-5-one, 2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-;Skepinone-L, >=98%;3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one;(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann;Skepinone-L;2-[(2,4-Difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one;CS-1010;SKEPINONE | | CAS: | 1221485-83-1 | | MF: | C24H21F2NO4 | | MW: | 425.42 | | EINECS: | | | Product Categories: | MAPK;Inhibitors | | Mol File: | 1221485-83-1.mol |  |
| | Skepinone-L Chemical Properties |
| Melting point | 130-134°C | | Boiling point | 629.0±55.0 °C(Predicted) | | density | 1.384±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 13.49±0.20(Predicted) | | form | Solid | | color | Light Yellow to Yellow |
| | Skepinone-L Usage And Synthesis |
| Description | Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC50 = 25 nM) or TNF-α in THP-1 cells. At 1 μM, it prevents phosphorylation of cytosolic phospholipase A2 in platelets in response to collagen-related peptide or thrombin , blunting platelet secretion and aggregation. | | Uses | Skepinone-L is a potent and highly selective inhibitor of p38 MAP kinase which impairs platelet activation and thrombus formation. | | target | p38-MAPK | | references | [1]. koeberle, s c et al., skepinone-l is a selective p38 mitogen-activated protein kinase inhibitor. nature chemical biology, 2012, 8(2), 141-143. |
| | Skepinone-L Preparation Products And Raw materials |
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