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| | 2-Acetylthiophene Chemical Properties |
| Melting point | 10-11 °C (lit.) | | Boiling point | 214 °C (lit.) | | density | 1.168 g/mL at 25 °C (lit.) | | vapor pressure | 2.7 hPa (50 °C) | | refractive index | n20/D 1.565(lit.) | | Fp | 196 °F | | storage temp. | Store below +30°C. | | solubility | 14g/l | | form | Liquid | | color | Clear pale yellow to light brown | | Odor | at 100.00 %. sulfurous nutty hazelnut walnut | | Odor Type | sulfurous | | Water Solubility | Insoluble in water. | | Sensitive | Light Sensitive | | BRN | 107910 | | InChIKey | WYJOVVXUZNRJQY-UHFFFAOYSA-N | | LogP | 1.250 | | CAS DataBase Reference | 88-15-3(CAS DataBase Reference) | | NIST Chemistry Reference | Ethanone, 1-(2-thienyl)-(88-15-3) | | EPA Substance Registry System | Ethanone, 1-(2-thienyl)- (88-15-3) |
| Hazard Codes | T,Xi,Xn | | Risk Statements | 25-23/24/25-20/21/22 | | Safety Statements | 45-38-36/37/39-28-36 | | RIDADR | UN 2810 6.1/PG 2 | | WGK Germany | 3 | | RTECS | OB6300000 | | F | 13 | | Autoignition Temperature | 265 °C DIN 51794 | | Hazard Note | Irritant | | TSCA | Yes | | HazardClass | 6.1 | | PackingGroup | II | | HS Code | 29349990 | | Toxicity | LD50 orally in Rabbit: 25 - 200 mg/kg LD50 dermal Rat 370 mg/kg |
| | 2-Acetylthiophene Usage And Synthesis |
| Description | 2-Acetylthiophene occurs naturally in kohlrabi. It has a sulfurous nutty hazelnut odor. It can be used as a food additive. It is also used as an intermediate to produce drugs, such as Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc.
| | Chemical Properties | clear colorless to slightly yellow liquid | | Uses | 2-Acetylthiophene is used as an intermediate in the manufacturing of drugs like Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc. | | Definition | ChEBI: 2-Acetylthiophene is an aromatic ketone. | | Synthesis Reference(s) | Organic Syntheses, Coll. Vol. 2, p. 8, 1943
The Journal of Organic Chemistry, 36, p. 540, 1971 DOI: 10.1021/jo00803a011
Tetrahedron Letters, 40, p. 3109, 1999 DOI: 10.1016/S0040-4039(99)00476-1 | | Safety Profile | Poison by intraperitoneal route. A flammable liquid. When heated to decomposition emits toxic fumes of SOx,. | | Purification Methods | Fractionally distil the thiophene through a 12-plate column, and fraction b 77o/4mm is collected. Also wet the acetylthiophene in order to remove and free thiophene which forms an azeotrope with H2O, b 68o. Store it in a brown bottle, and the clear colourless liquid remains thus for extended periods. [Kosak & Hartough Org Synth Coll Vol III 14 1955, Hartough & Kosak J Am Chem Soc 69 3093 1947.] The red 4-nitrophenylhydrazone crystallises from EtOH with m 181-182o. [Beilstein 17/9 V 387.] |
| | 2-Acetylthiophene Preparation Products And Raw materials |
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