4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile

4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile Basic information
Product Name:4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile
Synonyms:4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile;Erlotinib interMediate;2-nitro-4,5-bis(2-Methoxyethoxy)benzonitrile;4,5-Di(2-methoxyethoxy)-2-nitrobenzonitrile;Erlotinib Hydrochloride iMpurity 11;Erlotinib Hydrochloride iMpurity 16;Erlotinib-12;Erlotinib Impurity W
CAS:236750-65-5
MF:C13H16N2O6
MW:296.28
EINECS:1308068-626-2
Product Categories:
Mol File:236750-65-5.mol
4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile Structure
4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile Chemical Properties
Boiling point 459.3±45.0 °C(Predicted)
density 1.26±0.1 g/cm3(Predicted)
storage temp. 2-8°C
Safety Information
MSDS Information
4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile Usage And Synthesis
Uses4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile is an impurity of Erlotinib (E625008), a EGFR-targeted drug in the treatment of non-small cell lung cancer. EGFR small tyrosine kinase inhibitor that shows most substantial effect on tumor growth inhibition and animal survival.
4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile Preparation Products And Raw materials
Preparation ProductsErlotinib
Erlotinib iMpurity 2 Erlotinib Imp.15 Erlotinib Imp.5 Erlotinib Impurity 30 Erlotinib Impurity 38 Erlotinib Imp.9 2,3,5-Trimethylpyridine-1-Oxide 4-Quinazolinamine,N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)- Erlotinib Impurity 31 2-Amino-4,5-bis-(2-methoxy-ethoxy)-benzoic acid >98% Erlotinib Impurity 28 Erlotinib IMpurity C Erlotinib Impurity 67 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-hydroxyethoxy)quinazoline 4-QuinazolinaMine, 7-(2-chloroethoxy)-N-(3-ethynylphenyl)-6-(2-Methoxyethoxy)- Desmethyl Erlotinib Acetate Erlotinib iMpurity 2-Amino-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester hydrochloride

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