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| | Chonglou Saponin VII Basic information |
| Product Name: | Chonglou Saponin VII | | Synonyms: | Chonglou Saponin VII;Paris VII;Chonglouoside Ⅶ;Paris saponin VII;Dioscinin;Chonglou saponin Ⅶ;β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[O-6-deoxy-α-L-mannopyranosyl-(1→4)-6-deoxy-α-L-mannopyranosyl-(1→4)]-;Polyphyllin VIT | | CAS: | 68124-04-9 | | MF: | C51H82O21 | | MW: | 1031.2 | | EINECS: | | | Product Categories: | | | Mol File: | 68124-04-9.mol |  |
| | Chonglou Saponin VII Chemical Properties |
| Melting point | 243-245 °C (decomp) | | density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | -20°C, protect from light | | solubility | Soluble in methanol; | | form | powder | | pka | 12?+-.0.70(Predicted) | | color | White | | Water Solubility | sparingly soluble in water |
| | Chonglou Saponin VII Usage And Synthesis |
| Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents. | | Uses | Used for content determination/identification/pharmacological experiments, etc. | | Biological Activity | Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with inhibition of Akt/p38 MAPK and P-gp. It attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins (Bax and cytochrome c), and reduces the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1 and p-Akt. Paris saponin VII induces strong autophagy in K562/ADR cells, which can be used for leukemia research. | | Pharmacology | Chonglou saponin VII has the functions of anti-inflammatory, anti-tumor, anti-viral, lowering cholesterol, lowering blood pressure and so on. | | in vitro | Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. It significantly suppresses cell proliferation by cell cycle arrest in the G0 /G1 phase. | | in vivo | Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice. | | target | | Akt | p38 | Bcl-2 | Caspase-9 | Caspase-3 | PARP-1 | |
| | Chonglou Saponin VII Preparation Products And Raw materials |
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