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| | 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester Basic information |
| Product Name: | 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester | | Synonyms: | Ulmus pumila saponin I;3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester;Kudinoside H;Zigu-glucoside I;Gouguside 7;Ziyu-glycoside Ⅰ;Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, β-D-glucopyranosyl ester, (3β)-;[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate | | CAS: | 35286-58-9 | | MF: | C41H66O13 | | MW: | 766.95 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 35286-58-9.mol |  |
| | 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester Chemical Properties |
| Melting point | 198-202 ºC | | Boiling point | 841.9±65.0 °C(Predicted) | | density | 1.35 | | storage temp. | -20°C, protect from light | | solubility | Soluble in acetonitrile and methanol; | | pka | 12.52±0.70(Predicted) | | form | powder | | color | White | | Water Solubility | insoluble in water |
| | 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester Usage And Synthesis |
| Chemical Properties | White crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Burnet. | | Uses | Used for content determination/identification/pharmacological experiments, etc. | | Biological Activity | Ziyuglycoside I, isolated from the roots of S. officinalis, has anti-wrinkle activity and increases collagen type I expression. It can be used as an active ingredient in cosmetics and induces p53-mediated cell cycle arrest and apoptosis (apoptosis), which can be used in the study of triple-negative breast cancer. | | Physiological effects | Ziyuglycoside I has the functions of vasoconstriction, hemostasis and antifungal. | | in vitro | Ziyuglycoside I (5-160 μM; 24 hours) reveals a marked anti-proliferation activity with an IC 50 value of 13.96 μM in MDA-MB-231 cells. Ziyuglycoside I ( 5-20 μM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 μM. Ziyuglycoside I (5-20 μM; 24 hours) induces the cleavage of caspas- 8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression. Cell Viability Assay | Cell Line: | MDA-MB-231 cells < /td> | | Concentration: | 5 μM, 10 μM, 20 μM, 40 μM, 80 μM, and 160 μM | | Incubation Time: | 24 hours | | Result: | Showed cytotoxicity on MDA-MB-231 cells. | Cell Cycle Analysis | Cell Line: | MDA-MB-231 cells | | Concentration: | 5 μM, 10 μM, and 20 μM | | Incubation Time: | 24 hours | | Result: | Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells | Western Blot Analysis | Cell Line: | MDA-MB-231 cells | | Concentration: | 5 μM, 10 μM, and 20 μM | | Incubation Time: | 24 hours | | Result: | Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways. | |
| | 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester Preparation Products And Raw materials |
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