|
| Product Name: | GADOLINIUM CHLORIDE | | Synonyms: | Gadolinium(III) chloride,99.9%,anhydrous;Trichlorogadolinium;Gadolinium chloride anhydrous/ 99.9%;GadoliniuM(III) chloride, 99.9%, (trace Metal basis), anhydrous;GadoliniuM(III) chloride, anhydrous, 99.9% 5GR;Gadolinium(III) chloride, anhydrous, 99.9%;GADOLINIUM CHLORIDE, 99.9% ANHYDROUS;Gadolinium(III)chloride,anhydrous(99.9%-Gd)(REO) | | CAS: | 10138-52-0 | | MF: | Cl3Gd | | MW: | 263.61 | | EINECS: | 233-386-6 | | Product Categories: | metal halide;Alphabetic;Alphabetical Listings;Analytical Standards;Catalysis and Inorganic Chemistry;NMR Reference Standards;GadoliniumAnalytical Standards;NMRStable Isotopes;Spectroscopy;Chemical Synthesis;Crystal Grade Inorganics;Gadolinium Salts;GadoliniumMetal and Ceramic Science;Salts;Inorganics;G-HChemical Synthesis;GStable Isotopes;64: Gd;Gadolinium Salts;Beaded Materials;Materials Science;Metal and Ceramic Science;Other Metal | | Mol File: | 10138-52-0.mol |  |
| | GADOLINIUM CHLORIDE Chemical Properties |
| Melting point | 609°C | | density | 4,52 g/cm3 | | storage temp. | Hygroscopic, Room Temperature, under inert atmosphere | | solubility | Water | | form | powder | | color | White to off-white | | Specific Gravity | 4.52 | | Water Solubility | Soluble in water. | | Sensitive | Hygroscopic | | Merck | 14,4326 | | Stability: | hygroscopic | | CAS DataBase Reference | 10138-52-0(CAS DataBase Reference) | | EPA Substance Registry System | Gadolinium chloride (GdCl3) (10138-52-0) |
| Hazard Codes | Xi | | Risk Statements | 38 | | Safety Statements | 36/37 | | WGK Germany | 3 | | RTECS | ZC0230000 | | F | 10-21 | | TSCA | Yes | | HS Code | 28273985 |
| | GADOLINIUM CHLORIDE Usage And Synthesis |
| Physical Properties | White monoclinic crystal; hygroscopic; density 4.52 g/cm3; melts at 609°C; soluble in water.
| | Preparation | GdCl3 is prepared by heating gadolinium(III) oxide with excess of ammonium chloride above 200°C:
Gd2O3 + 6NH4Cl→2GdCl3 + 6NH3 + 3H2O
| | Chemical Properties | Colorless crystals, soluble in water, purities up to 99.9%. | | Uses | Gadolinium(III) Chloride is used as chelating agents, which is essential for biomedical applications. It is also employed in the synthesis and nuclear magnetic resonance (NMR) studies of paramagnetic GdPCTA-[12] and GdPCTA-[13] complexes. It plays an important role as contrast agent for magnetic resonance imaging and an macrophage inhibitor. | | Uses | GadoliniuM chloride, anhydrous is a calcium-sensing receptor agonist and is known to work by inducing NLRP3 inflammasome activation in bone marrow-derived macrophages.
GdCl3 is used for preparing gadolinium metal.
| | Definition | ChEBI: Gadolinium trichloride is a gadolinium coordination entity. It has a role as a TRP channel blocker. | | Biological Activity | gadolinium chloride is a casr agonist. the casr can activate the nlrp3 inflammasome by increasing intracellular ca2+ and decreasing cellular cyclic amp. thus, casr agonists may serve as a useful tool for exploring nlrp3 inflammasome associated inflammatory diseases such as cryopyrin-associated periodic syndromes, gout and atherosclerosis. in addition, gadolinium chloride has been demonstrated to block trpml channel currents, as well as other transient receptor potential (trp) channels.1. lee gs, subramanian n, kim ai, et al. the calcium-sensing receptor regulates the nlrp3 inflammasome through ca2+ and camp. nature, 2012, 492(7427): 123-127.2. nagata k, zheng l, madathany t, et al. the varitint-waddler (va) deafness mutation in trpml3 generates constitutive, inward rectifying currents and causes cell degeneration. proceedings of the national academy of sciences of the united states of america, 2008, 105(1): 353-358.3. del favero g, florio c, codan b, et al. the stretch-activated channel blocker gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. chemical research in toxicology, 2012, 25(9): 1912-1920. | | storage | Desiccate at RT |
| | GADOLINIUM CHLORIDE Preparation Products And Raw materials |
|
