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| | (R)-(+)-Ketorolac Basic information |
| | (R)-(+)-Ketorolac Chemical Properties |
| Melting point | 163-170°C | | storage temp. | -20°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | powder | | color | white to beige | | optical activity | [α]/D +162 to +178°, c = 1 in methanol |
| | (R)-(+)-Ketorolac Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | (R)-Ketorolac is the R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory. | | Definition | ChEBI: A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has R configuration. Unlike the S-enantiomer, it does not exhibit COX1 and COX2 inhibition, but does exhibit analgesic activity. Racemic keto
olac, known simply as ketorolac, is used (mainly as a tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. | | Biochem/physiol Actions | R-Ketorolac is potent and selective Rho-family GTPases Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) allosteric inhibitor that modulates downstream GTPase-dependent physiologic responses critical to tumor metastasis. R-ketorolac significantly inhibits ovarian cancer cell adhesion, migration, and invasion. |
| | (R)-(+)-Ketorolac Preparation Products And Raw materials |
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