ChemicalBook Product Catalog Biochemical Engineering Amino Acids and proteins D-Norleucine

D-Norleucine

D-Norleucine Basic information
Product Name:D-Norleucine
Synonyms:D-Norleucine;H-D-2-AMINOCAPROIC ACID;H-D-ACPO(2)-OH;H-D-AHX(2)-OH;H-D-NLE-OH;H-D-NORLEUCINE;D-2-AMINO CAPROIC ACID;D-2-AMINOHEXANOIC ACID
CAS:327-56-0
MF:C6H13NO2
MW:131.17
EINECS:206-320-9
Product Categories:Leucine [Leu, L];Amino Acids;AMINO ACIDS;Amino Acid Derivatives
Mol File:327-56-0.mol
D-Norleucine Structure
D-Norleucine Chemical Properties
Melting point ≥300 °C
alpha [α]D20 -23.0～-25.0゜ (c=4, HCl)
Boiling point 234.0±23.0 °C(Predicted)
density 1.1720 (estimate)
refractive index -23 ° (C=4.5, 6mol/L HCl)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka2.55±0.24(Predicted)
form powder to crystal
color White
Water Solubility 15.75g/L(19 ºC)
Merck 14,6706
BRN 1721749
InChIKeyLRQKBLKVPFOOQJ-RXMQYKEDSA-N
CAS DataBase Reference327-56-0(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
WGK Germany 3
HS Code 29224999
MSDS Information
ProviderLanguage
D-2-Aminohexanoic acid English
SigmaAldrich English
ALFA English
D-Norleucine Usage And Synthesis
Chemical Propertieswhite to off-white crystalline powder or flakes
UsesD-Norleucine is used for the synthesis of Thailandepsin B, a bicyclic depsipeptide histone deacetylase inhibitor.
DefinitionChEBI: D-norleucine is the D-enantiomer of 2-aminohexanoic acid. It is an enantiomer of a L-norleucine. It is a tautomer of a D-norleucine zwitterion.
Purification MethodsCrystallise norleucine from water or aqueous MeOH. [Huffman & Ingersoll J Am Chem Soc 73 3366 1951, Beilstein 4 III 1386, 4 IV 2628.]
D-Norleucine Preparation Products And Raw materials
Preparation ProductsDL-Norleucine-->D-Norleucine, 2-(aminomethyl)- (9CI)-->AC-D-NLE-OH
N,N'-Dibenzyloxycarbonyl-D-lysine Ethyl 2-(Chlorosulfonyl)acetate 1-Amino-1-cyclohexanecarboxylic acid Leucine aminopeptidase，porcine kidney Hexanoic acid ALTRENOGEST N-ALPHA-T-BUTOXYCARBONYL-D-NORLEUCINE,N-ALPHA-TERT-BUTYLOXYCARBONYL-D-NORLEUCINE Folic acid D-Norleucine 6-Aminocaproic acid Glycine L-Norleucine DL-2-AMINOADIPIC ACID 6-DIAZO-5-OXO-D-NORLEUCINE phosphoric acid AMINO ACIDS Z-D-NLE-ONP N-CARBOBENZOXY-DL-LEUCINE
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