Cyclobutanemethanol

Cyclobutanemethanol Basic information

Product Name:	Cyclobutanemethanol
Synonyms:	(HYDROXYMETHYL)CYCLOBUTANE;CYCLOBUTANECARBINOL;CYCLOBUTANEMETHANOL;RARECHEM AK ML 0579;Cyclobutanemethanol,99%;Cyclobutylcarbinol~Hydroxymethylcyclobutane;Cyclobutylmethyl alcohol;Cyclobutane-1-methanol
CAS:	4415-82-1
MF:	C5H10O
MW:	86.13
EINECS:	224-575-4
Product Categories:	Benazir bhutto, Nadine brown brown, analgesic, such as intermediates.;API intermediates;Cyclobutanes & Cyclobutenes;Simple 4-Membered Ring Compounds;Cycloalkanes;Alcohols;C2 to C6;Oxygen Compounds
Mol File:	4415-82-1.mol

Cyclobutanemethanol Chemical Properties

Melting point	68.5 °C
Boiling point	143-144 °C(lit.)
density	0.913 g/mL at 25 °C(lit.)
refractive index	n20/D 1.446(lit.)
Fp	104 °F
storage temp.	Sealed in dry,2-8°C
pka	15.26±0.10(Predicted)
form	Liquid
color	Clear colorless
Water Solubility	immiscible
BRN	2036027
InChIKey	WPOPOPFNZYPKAV-UHFFFAOYSA-N
CAS DataBase Reference	4415-82-1(CAS DataBase Reference)
NIST Chemistry Reference	Cyclobutanemethanol(4415-82-1)

Safety Information

Risk Statements	10
Safety Statements	16-24/25
RIDADR	UN 1987 3/PG 3
WGK Germany	3
HazardClass	3
PackingGroup	III
HS Code	29061900

MSDS Information

Provider	Language
Hydroxymethylcyclobutane	English
SigmaAldrich	English
ACROS	English
ALFA	English

Cyclobutanemethanol Usage And Synthesis

Chemical Properties	Colorless to Almost colorless clear liquid.
Uses	Cyclobutanemethanol was used in the synthesis of bicyclic lactone.
Application	Cyclobutanemethanol is a drug used to treat inflammatory diseases. It is an uptake inhibitor that blocks the transport of uridine into cells, preventing the activation of G-protein coupled receptors and the subsequent production of inflammatory mediators. Cyclobutanemethanol has been shown to have anti-inflammatory properties by inhibiting the CB2 receptor, which is found in large quantities in inflammatory tissues. It also prevents dehydration and increases blood flow to inflamed areas by acting on vascular endothelial cells. It has been shown to inhibit influenza virus replication in vitro, but not in vivo.
General Description	Oxidation of cyclobutanemethanol in the presence of lead tetraacetate and lead tetraacetate/metal chloride has been investigated.
Synthesis	Cyclobutanemethanol can be synthesized from two molecules of hydrochloric acid and one molecule of cyclobutane. The synthesis pathway includes removal of a hydroxy group and addition of an alkynyl group via hydrogen bonding interactions with chloride ions.

Cyclobutanemethanol Preparation Products And Raw materials

Raw materials

Sodium ethoxide-->1-Bromo-3-chloropropane-->Cyclobutanecarboxylic acid-->Diethyl 1,1-cyclobutanedicarboxylate-->1,1-Cyclobutanedicarbonyl dichloride (9CI)-->Cyclobut-2-enyl-methanol-->1-Cyclobutene-1-methanol-->3-ChlorocyclobutaneMethanol-->3-CHLOROCYCLOBUTANECARBOXYLIC ACID-->3-chlorocyclobutane-1,1-dicarboxylic acid-->Cyclobutene-1-carboxylic acid methyl ester-->1-Chycobutane carboxylic acid-->4-BROMOBENZENESULFONIC ACID MONOHYDRATE

Preparation Products

(Bromomethyl)cyclobutane-->Cyclobutanecarboxaldehyde-->IODOCYCLOPENTANE

1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER Cyclobutanemethanol, 3-hydroxy-2-methylene-, alpha-acetate, (1R,3R)- (9CI) Diisobutylcarbinol CIS-1,2-CYCLOBUTANEDICARBOXYLIC ACID DIMETHYL ESTER PINANOL 85 Cyclobutanemethanol,2-amino-,cis-(9CI) Ethyl cyclobutanecarboxylate CIS-CYCLOBUTANE-1,2-DICARBOXYLIC ACID 1,2,3,4-CYCLOBUTANETETRACARBOXYLIC ACID AURORA KA-477 Cyclobutanemethanol, 3-amino-2,2-dimethyl-, (1S,3R)- (9CI) Cyclobutanemethanol, 2,2-dimethyl-3-(1-methylethylidene)-, (1R)- (9CI) cis-VERBENOL cyclobutanemethanol, 1-[(methylamino)methyl]- CYCLOBUTYL-HYDROXY-PHENYL-ACETIC ACID 2,2,3,3-tetrafluorocyclobutanemethanol Cyclobutanemethanol, 1-(aminomethyl)-3-(1-methylethyl)- (9CI) Cyclobutanemethanol,3-amino-,cis-(9CI)

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