ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound 4-Chloro-N-methylpiperidine

4-Chloro-N-methylpiperidine

4-Chloro-N-methylpiperidine Basic information
Product Name:4-Chloro-N-methylpiperidine
Synonyms:4-chloro-1-methyl-piperidin;4-CHLORO-N-METHYL PIPERIDINE;(2Z)-2-(1-amino-3-methyl-2-benzimidazolylidene)-2-cyanoacetic acid ethyl ester;4-chloro-n-methylpiperidine Hydrochloride CAS 5570-77-4;4-CHLORO-1-METHYLPIPERIDINE;1-METHYL-4-CHLORO-PIPERIDINE;N-METHYL-4-CHLORO PIPERIDINE;N- METHYL 4 CHLORO PIPERIDINE BASE
CAS:5570-77-4
MF:C6H12ClN
MW:133.62
EINECS:226-942-4
Product Categories:Heterocyclic Compounds;PHARMACEUTICAL INTERMEDIATES;5570-77-4
Mol File:5570-77-4.mol
4-Chloro-N-methylpiperidine Structure
4-Chloro-N-methylpiperidine Chemical Properties
Melting point 160-165°C
Boiling point 162°C(lit.)
density 1.02
vapor pressure 3.493hPa at 25℃
refractive index 1.4670-1.4710
Fp 48 °C
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), Ethanol (Slightly) , Methanol (Slightly)
pka7.88±0.10(Predicted)
form clear liquid to slightly cloudy liquid
color Colorless to Light yellow to Light orange
Water Solubility 1.533g/L at 29℃
InChIKeyMYGXGCCFTPKWIH-UHFFFAOYSA-N
LogP1.318 at 25℃
CAS DataBase Reference5570-77-4(CAS DataBase Reference)
EPA Substance Registry SystemPiperidine, 4-chloro-1-methyl- (5570-77-4)
Safety Information
Hazard Codes Xi,C
Risk Statements 10-34-36/38
Safety Statements 22-24/25-45-36/37/39-26-36-16
RIDADR 1993
HazardClass 3
PackingGroup III
HS Code 29333990
MSDS Information
4-Chloro-N-methylpiperidine Usage And Synthesis
Chemical PropertiesClear colorless liquid
Uses4-Chloro-1-methylpiperidine is a reactant in the synthesis of indole and benzimidazole piperazines as histamine H4 receptor antagonist.
Flammability and ExplosibilityNotclassified
Physiological effects4-Chloro-N-methylpiperidine can be used to treat bronchial asthma, chronic obstructive pulmonary disease, and other respiratory disorders by inhibiting the production of histamine in the body. It also has antihistaminic effects that may be due to its ability to inhibit histamine release from mast cells or block H1 receptors.
2-CHLORO-6-NITROANILINE Indole-4-carboxaldehyde 1,2-Propyleneglycol diacetate 1-Methyl-3-piperidinemethanol 1-Methyl-4-piperidinemethanol N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER Triacetonediamine CHLOROMETHYLPHENYLSILANE 4-Chloropiperidine Chloromethyl methyl ether 2-Chloro-5-chloromethylpyridine tert-Butyldimethylsilyl chloride Chlorine 4-Chloro-N-methylpiperidine Difluorochloromethane 4-Chloro-1-methylpiperidine hydrochloride Chloromethyltrimethylsilane Chloromethane
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