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| | L-Homocystine Basic information |
| Product Name: | L-Homocystine | | Synonyms: | (2S,2'S)-2,2'-Diamino-(4,4'-dithiobisbutyric acid);3,3'-(Dithiobismethylene)bisalanine;4,4'-Dithiobis[(2S)-2-aminobutanoic acid];4,4'-Dithiobis[(S)-2-aminobutanoic acid];4,4'-Dithiobis[(S)-2-aminobutyric acid];(2S,2'S)-4,4'-Dithiobis[2-aMinobutanoic Acid];[S-(R*,R*)]-4,4'-Dithiobis[2-aMinobutanoic Acid];L-Homocystine ,99% | | CAS: | 626-72-2 | | MF: | C8H16N2O4S2 | | MW: | 268.35 | | EINECS: | 210-962-5 | | Product Categories: | Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Amino Acids | | Mol File: | 626-72-2.mol |  |
| | L-Homocystine Chemical Properties |
| Melting point | 281-284 °C (dec.)(lit.) | | alpha | 77 º (c=1% in 1N HCl) | | Boiling point | 507.6±50.0 °C(Predicted) | | density | 1.443±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | H2O : 5 mg/mL (18.63 mM; ultrasonic and adjust pH to 3 with H2O)DMSO : 1 mg/mL (3.73 mM; ultrasonic and adjust pH to 5 with HCl) | | form | Powder | | pka | 1.90±0.10(Predicted) | | BRN | 1728583 | | InChIKey | ZTVZLYBCZNMWCF-WDSKDSINSA-N | | CAS DataBase Reference | 626-72-2(CAS DataBase Reference) | | EPA Substance Registry System | L-Homocystine (626-72-2) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29309090 |
| | L-Homocystine Usage And Synthesis |
| Chemical Properties | White powder | | Uses | Increased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer. | | Definition | ChEBI: L,L-homocystine is a homocystine in which both chiral centres have L configuration. It is functionally related to a L-homocysteine. It is a tautomer of a L,L-homocystine zwitterion. | | Purification Methods | The acid (3g) is dissolved in freshly boiled H2O (30mL) under N2, cooled under N2 (all operations should be under N2), absolute EtOH (100mL) is added, the acid is filtered off, and a second crop is obtained by diluting the filtrate to 500mL with absolute EtOH, kept overnight in a refrigerator, filtered, washed with EtOH and dried in a vacuum. The D(R,R)-form has similar properties but is –ve in M HCl and +ve in H2O. [du Vigneaud & Patterson J Biol Chem 109 101 1935, du Vigneaud & Brown Biochemical Preparations 5 93, 95 1975, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2667-2670 1961, Beilstein 4 III 1643, 4 IV 3199, Koegel et al. J Am Chem Soc 77 5708 1955.] |
| | L-Homocystine Preparation Products And Raw materials |
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