ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Basic information
Product Name:4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE
Synonyms:4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE;2-Pyridinecarboxamide,4-(4-amino-3-fluorophenoxy)-N-methyl-;4-(4-Amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamine;4-(4-amino-3-fluorophenoxy);4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamid;Regorafenib Impurity 35;4-(4-Amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamide;4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
CAS:757251-39-1
MF:C13H12FN3O2
MW:261.25
EINECS:692-721-8
Product Categories:Regorafenib
Mol File:757251-39-1.mol
4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Structure
4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Chemical Properties
Melting point 143 °C
Boiling point 459.8±45.0 °C(Predicted)
density 1.305
vapor pressure 0Pa at 20℃
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
form Solid
pka13.92±0.46(Predicted)
color Orange to Dark Red to Brown
Water Solubility 190mg/L at 20℃
LogP1.3 at 25℃
Safety Information
HS Code 2933.39.9200
MSDS Information
4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Usage And Synthesis
Uses4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide is a compound used as a reagent to synthesize Regorafenib (R143000), a multikinase inhibitor that is used to treat patients with advanced colorectal cancer.
DefinitionChEBI: 4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide is an aromatic ether.
4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Preparation Products And Raw materials
Raw materials4-bromo-N-methylpicolinamide-->N-Methyl-4-chloropyridine-2-carboxamide
Preparation ProductsRegorafenib
Regorafenib Cabozantinib Impurity E 2-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-3,3-diphenyl-2-propenoic Acid 6,6'-bis(2-methyl-2H-tetrazol-5-yl)-3,3'-bipyridine S-Silodosin 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine PAROXETINE RELATED COMPOUND C (15 MG) ((+)-TRANS-PAROXETINE HYDROCHLORIDE) (4-BENZYLOXYCARBONYLAMINOPHENYL)BORONIC ACID, PINACOL ESTER Selexipag Impurity 6 Paroxetine 4-(4-Fluorophenyl)-1-Methyl- 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrate 4-Amino-3-fluorophenol 4-(4-Aminophenoxy)-N-methylpicolinamide 2-Pyridinemethanamine,4-methoxy-(9CI) 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE 4-(4-AMINOPHENOXY)PYRIDINE 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE
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