ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatic ketones 4'-Fluoro-2'-hydroxyacetophenone

4'-Fluoro-2'-hydroxyacetophenone

4'-Fluoro-2'-hydroxyacetophenone Basic information
Product Name:4'-Fluoro-2'-hydroxyacetophenone
Synonyms:4'-FLUORO-2'-HYDROXYACETOPHENONE;4-FLUORO-2-HYDROXYACETOPHENONE;4-Fluoro-2-hydroxyacethophenone, 98%;4'-Fluoro-2'-hydroxyacetophenone 98%;4'-Fluoro-2'-hydroxyacetophenone98%;4'-fluoro-2'-hydroxyacetophenone,1-(4-fluoro-2-hydroxyphenyl)ethanone;4-FLUORO-2-HYDROXYACETOPHE;uoro-2'-hydroxyacetophenone
CAS:1481-27-2
MF:C8H7FO2
MW:154.14
EINECS:
Product Categories:Aromatic Acetophenones & Derivatives (substituted);ketone;Adehydes, Acetals & Ketones;Fluorine Compounds;Phenols;C7 to C8;Carbonyl Compounds;Ketones
Mol File:1481-27-2.mol
4'-Fluoro-2'-hydroxyacetophenone Structure
4'-Fluoro-2'-hydroxyacetophenone Chemical Properties
Melting point 32-34°C
Boiling point 65°C 2mm
density 1.1850 (estimate)
Fp 98°C
storage temp. Inert atmosphere,Room Temperature
pka9.17±0.10(Predicted)
form powder to lump
color White to Almost white
BRN 2249799
InChIKeyHLTBTUXAMVOKIH-UHFFFAOYSA-N
CAS DataBase Reference1481-27-2(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36/37/39-36
WGK Germany 3
HazardClass IRRITANT
HS Code 29147000
MSDS Information
ProviderLanguage
ALFA English
4'-Fluoro-2'-hydroxyacetophenone Usage And Synthesis
Chemical PropertiesColorless to yellow liquid
Uses4′-Fluoro-2′-hydroxyacetophenone may be used in the preparation of series of 4′-fluoro-2′-hydroxychalcones, via aldol condensation with substituted aldehydes followed by cyclization with hydrazine hydrate.
PreparationPreparation by Fries rearrangement of 3-fluorophenyl acetate with aluminium chloride without solvent at 160–180° (75%) (88–90%).
General Description4′-Fluoro-2′-hydroxyacetophenone is a substituted acetophenone derivative. Biological Baeyer-Villiger oxidation of 4′-fluoro-2′-hydroxyacetophenone to 4-fluorocatechol by using whole cells of Pseudomonas fluorescens ACB has been reported. Its crystals belong to the monoclinic crystal system and space group P21/n.
4'-Fluoro-2'-hydroxyacetophenone Preparation Products And Raw materials
Raw materials2',4'-Difluoroacetophenone-->1-ACETOXY-3-FLUOROBENZENE-->2'-Fluoro-4'-hydroxyacetophenone
Preparation Products6-Fluoro-3(2H)-benzofuranone-->1-(2-ethoxy-4-fluorophenyl)ethanone-->4-Fluoro-2-methoxyphenol
7-Fluoro-4-chromanone Fluorine 1-(5-Bromo-4-fluoro-2-hydroxyphenyl)ethanone 2',4',6'-Trihydroxyacetophenone monohydrate 3-FLUOROXANTHEN-9-ONE 4-Fluoro-2-hydroxyphenacyl bromide 2,4-Dihydroxyacetophenone 3-Nitroacetophenone 4-Nitroacetophenone 4'-Fluoro-2'-hydroxyacetophenone 6-FLUOROCHROMONE-3-PROPIONIC ACID Acetophenone IFLAB-BB F2108-0161 5,6,7,8-TETRAFLUORO-2-METHYL-4-OXO-4H-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER 4-FLUORO-2-METHOXYACETOPHENONE 6-Fluoro-3(2H)-benzofuranone 4-Aminoacetophenone 2',6'-Dihydroxyacetophenone
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