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| | Bupropion hydrochloride Basic information |
| Product Name: | Bupropion hydrochloride | | Synonyms: | (+-)-alpha-tert-butylamino-3-chloropropiophenonehydrochloride;1-propanone,1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-,hydrochloride,;2-(tert-butylamino)-3’-chloro-,hydrochloride,(+-)-propiophenon;Bupropion hydrochloride,(±)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride;Bupropion Hydrochloride (200 mg);m-chloro-alpha-tert-butylaminoprophenonehydrochloride;wellbatrin;Bupropion Hydrochloride, USP | | CAS: | 31677-93-7 | | MF: | C13H19Cl2NO | | MW: | 276.2 | | EINECS: | 250-759-9 | | Product Categories: | WELLBUTRIN;Amines;API;Isotope;Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals;Adrenoceptor;Aromatics Compounds;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 31677-93-7.mol |  |
| | Bupropion hydrochloride Chemical Properties |
| Melting point | 233-234 °C | | Fp | 9℃ | | storage temp. | Desiccate at RT | | solubility | ethanol: 193 mg/mL solutions may be stored for several days at 4 °C. | | form | solid | | color | white | | Water Solubility | Soluble in water (>25 mg/ml), ethanol 193mg/ml, 0.1 N HCl 333 mg/ml | | CAS DataBase Reference | 31677-93-7(CAS DataBase Reference) |
| | Bupropion hydrochloride Usage And Synthesis |
| Chemical Properties | Bupropion hydrochloride powder is white, crystalline, and highly soluble in water. It has a bitter taste and produces the sensation of local anesthesia on the oral mucosa. | | Originator | Bupropion
hydrochloride,AroKor Holdings
Inc. | | Drug interactions | Relatively few data are available on interactions of bupropion hydrochloride with other drugs. Increased adverse experiences were reported when the drug was administered concomitantly with l-dopa. MAOIs may increase the acute toxicity of bupropion.
Although bupropion is not metabolized by the CYP2D6 enzyme, the drug and its metabolite, morpholinol, inhibit this enzyme in vitro. Therefore, extreme caution should be exercised when coadministering any drug metabolized by that enzyme, and initial dosage of the drug should be as low as possible. | | Uses | Bupropion hydrochloride is indicated for the treatment of MDD. Bupropion hydrochloride SR (Zyban) is indicated as an aid to smoking cessation treatment. | | Brand name | Wellbutrin (GlaxoSmithKline); Zyban
(GlaxoSmithKline). | | Therapeutic Function | Antidepressant; Smoking cessation aid | | Biological Activity | Non-selective inhibitor of dopamine and noradrenalin transporters (K i values are 1.4, 2.8 and 45 μ M for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo . | | Side effects | Bupropion hydrochloride can cause serious side effects. The most common side effects of Bupropion hydrochloride include:
headache
dizziness
dry mouth
sore throat
nausea
constipation
trouble sleeping | | Mode of action | The exact mechanism of the antidepressant action of bupropion is not known, but is presumed to be related to noradrenergic and/or dopaminergic mechanisms. Bupropion is a relatively weak inhibitor of the neuronal reuptake of norepinephrine and dopamine, and does not inhibit the reuptake of serotonin. Bupropion does not inhibit monoamine oxidase. |
| | Bupropion hydrochloride Preparation Products And Raw materials |
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