|
| | licarin A Basic information |
| Product Name: | licarin A | | Synonyms: | licarin A;4-[(2S)-2,3-Dihydro-7-methoxy-3β-methyl-5-[(E)-1-propenyl]benzofuran-2-yl]-2-methoxyphenol;NSC 370989;Phenol, 4-[(2R,3R)-2,3-dihydro-7-methoxy-3-methyl-5-(1E)-1-propen-1-yl-2-benzofuranyl]-2-methoxy-;2-Methoxy-4-((2R,3R)-7-methoxy-3-methyl-5-((E)-prop-1-en-1-yl)-2,3-dihydrobenzofuran-2-yl)phenol | | CAS: | 51020-86-1 | | MF: | C20H22O4 | | MW: | 326.39 | | EINECS: | | | Product Categories: | | | Mol File: | 51020-86-1.mol |  |
| | licarin A Chemical Properties |
| storage temp. | 4°C, protect from light |
| | licarin A Usage And Synthesis |
| Biological Activity | Licarin A ((+)-Licarin A), which can be isolated from a variety of plants, significantly reduces dinitrophenylhydrazine-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. It has anti-allergic effect and reduces TNF-α and PGD2 production, and COX-2 expression. | | in vitro | Licarin A is found in plants such as Aristolochia taliscana , Machilus thunbergii and Myristica fragrans , which are used as spices and in folk medicines for nervous and digestive disorders. It also exhibits anti-inflammatory effects.
Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels. |
| | licarin A Preparation Products And Raw materials |
|
