ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatic acids 5-Nitrosalicylic acid

5-Nitrosalicylic acid

5-Nitrosalicylic acid Basic information
Product Name:5-Nitrosalicylic acid
Synonyms:2-hydroxy-5-nitro-benzoicaci;AURORA KA-2534;ANILOTIC ACID;2-HYDROXY-5-NITROBENZOIC ACID;RARECHEM AL BE 0192;TIMTEC-BB SBB006535;5-NITROSALICYLIC ACID;5-NITRO-2-HYDROXY-BENZOIC ACID
CAS:96-97-9
MF:C7H5NO5
MW:183.12
EINECS:202-548-8
Product Categories:C7;Carbonyl Compounds;Organic acids;API intermediates;Carboxylic Acids;Phenyls & Phenyl-Het;FINE Chemical & INTERMEDIATES;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
Mol File:96-97-9.mol
5-Nitrosalicylic acid Structure
5-Nitrosalicylic acid Chemical Properties
Melting point 228-230 °C(lit.)
Boiling point 316.77°C (rough estimate)
density 1,65 g/cm3
vapor pressure 0Pa at 25℃
refractive index 1.6280 (estimate)
storage temp. no restrictions.
solubility water: soluble1g in 1475ml(lit.)
pkapK1:2.12 (25°C)
form Liquid
color Clear yellow-beige to orange-brown
Water Solubility Soluble in water 1g/1475ml .
Merck 14,6631
BRN 2213719
InChIKeyPPDRLQLKHRZIJC-UHFFFAOYSA-N
LogP1.158 at 25℃
CAS DataBase Reference96-97-9(CAS DataBase Reference)
EPA Substance Registry SystemBenzoic acid, 2-hydroxy-5-nitro- (96-97-9)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
Hazard Note Irritant
TSCA Yes
HS Code 29182990
MSDS Information
ProviderLanguage
2-Hydroxy-5-nitrobenzoic acid English
SigmaAldrich English
ACROS English
ALFA English
5-Nitrosalicylic acid Usage And Synthesis
Chemical Propertiesyellow powder
Uses5-Nitrosalicylic Acid is a salicylic acid derivative with anti-inflammatory effect against colitis.
DefinitionChEBI: A monohydroxybenzoic acid in which the hydroxy group is ortho- to the carboxylic acid group and which has a nitro substituent para- to the phenolic hydroxy group.
Synthesis Reference(s)Tetrahedron Letters, 36, p. 2377, 1995 DOI: 10.1016/0040-4039(95)00281-G
General Description2-Hydroxy-5-nitrobenzoic acid inhibits the activity of wild type-bovine low Mr protein tyrosine phosphatase. The inhibition constant has been evaluated.
Flammability and ExplosibilityNonflammable
Purification MethodsCrystallise the acid from Me2CO (charcoal), then twice more from Me2CO alone, aqueous EtOH (m 234-236o) or H2O (m 232-233o). [Beilstein 10 III 197, 10 IV 255.]
5-Nitrosalicylic acid Preparation Products And Raw materials
Preparation Products5-Aminosalicylic acid-->3-Nitrosalicylic acid-->2,6-Diiodo-4-nitrophenol-->METHYL 5-AMINOSALICYLATE-->2-(HYDROXYMETHYL)-4-NITROBENZENOL-->METHYL 5-NITROSALICYLATE-->5-Hydroxy-2-nitrobenzoic acid-->N-[4-Chloro-3-(trifluoroMethyl)phenyl]-2-hydroxy-5-nitrobenzaMide-->N,2-dihydroxy-5-nitrobenzaMide
Methyl 3,5-dinitrosalicylate 3-CHLORO-2,6-DIMETHOXY-5-NITROBENZOIC ACID 3-BROMO-2,6-DIMETHOXY-5-NITROBENZOIC ACID METHYL 2,6-DIMETHOXY-3-NITROBENZOATE 4-Methylsalicylic acid p-Nitrobenzoic acid Acetylsalicylic acid 5-Nitrosalicylic acid 3,5-DINITRO-2-HYDROXYBENZOIC ACID SODIUM 2,3,4-Trihydroxybenzoic acid 4-Nitrophenyl chloroformate 3,5-Dihydroxybenzoic acid 5-NITROSALICYLIC ACID METHYL ESTER Sodium 3-nitrobenzoate 2,6-DIMETHOXY-3-NITROBENZOIC ACID 3,5-Dinitrosalicylic acid 2-[(5-CHLORO-3-PYRIDYL)OXY]-5-NITROBENZOIC ACID Citric acid
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