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| | dendrobine Basic information |
| Product Name: | dendrobine | | Synonyms: | (3α,6α,7R,8S,9R,10α,11α)-Dendrobane-12-one;Dendroban-12-one;12-Oxodendrobane;7,5-(EpoxyMethano)-1H-cyclopent[cd]indol-9-one,decahydro-1,7b-diMethyl-6-(1-Methylethyl)-, (2aS,4aS,5R,6S,7R,7aS,7bR)-;Dendrobine
Dendroban-12-one;Dendrobine 1%;Dendrobine, 98%, from Dendrobium nobile Lindl;Dendrobine 2115-91-5 | | CAS: | 2115-91-5 | | MF: | C16H25NO2 | | MW: | 263.38 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 2115-91-5.mol |  |
| | dendrobine Chemical Properties |
| Melting point | 135-136℃ | | Boiling point | 375℃ | | density | 1.101 | | Fp | 133℃ | | storage temp. | 4°C, protect from light | | solubility | ≥60mg/ml in MeOH | | form | Powder | | pka | 9.49±0.60(Predicted) |
| | dendrobine Usage And Synthesis |
| Description | Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity. It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 μg/ml. It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 μg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin at 10 μg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin. | | Uses | Dendrobine is an alkaloid isolated from Dendrobium nobile and is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord. | | Definition | ChEBI: Dendrobine is a member of indoles. |
| | dendrobine Preparation Products And Raw materials |
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