sphondin

sphondin Basic information
Product Name:sphondin
Synonyms:sphondin;6-Methoxy-2H-furo[2,3-h][1]benzopyran-2-one;6-Methoxy-2H-furo[2,3-h]-1-benzopyran-2-one;2H-Furo(2,3-h)-1-benzopyran-2-one, 6-Methoxy-;Sfondin;6-Methoxy-2H-furo[2,3-h]chromen-2-one
CAS:483-66-9
MF:C12H8O4
MW:216.19
EINECS:
Product Categories:
Mol File:483-66-9.mol
sphondin Structure
sphondin Chemical Properties
Melting point 189-191 °C
Boiling point 413.0±45.0 °C(Predicted)
density 1.368±0.06 g/cm3(Predicted)
storage temp. 2-8°C
Safety Information
Hazardous Substances Data483-66-9(Hazardous Substances Data)
MSDS Information
sphondin Usage And Synthesis
Chemical PropertiesOff-white needle-like crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Oxtail Duhuo.
UsesSphondin has an Analgesic, anti-inflammatory, anti-allergic, smooth muscle spasmolytic effect.
DefinitionChEBI: Sphondin is a furanocoumarin.
Biological ActivitySphondin, isolated from Heracleum laciniatum, has inhibitory effects on IL-1β-induced increases in COX-2 protein and PGE2 release levels in A549 cells.
in vitro

Pretreatment of A549 cells with Sphondin (10-50 μM) concentration-dependently attenuates IL-1β-induced COX-2 protein expression and PGE 2 release.

target

COX-2

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sphondin Preparation Products And Raw materials
DAURICINE 6-ISOPENTENYLOXYISOBERGAPTEN WEDELOLACTONE Hydroxyecdysone pimpinellin Deoxyelephantopin Isodeoxyelephantopin 8-O-acetyl shanzhiside methyl ester ATRACTYLON Salvianolic acid B Isoscabertopin Periplocoside Scabertopin daurisoline ISOBERGAPTEN hydroxysafflor yellow A 1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one alpha-Cyperone

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