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LICOCHALCONE-A

LICOCHALCONE-A Basic information
Product Name:LICOCHALCONE-A
Synonyms:LICOCHALCONE-A;(E)-3-[5-(1,1-DIMETHYL-2-PROPENYL)-4-HYDROXY-2-METHOXYPHENYL]-1-(4-HYDROXYPHENYL)-2-PROPEN-1-ONE;4′,4-Dihydroxy-3-α,α-dimethylallyl-6-methoxychalcone;2-Propen-1-one, 3-[5-(1,1-dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-, (2E)-;7-Dimethoxycoumarin;Licochalcone A, >=98%;(2E)-3-[4-Hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one;Soluble LICOCHALCONE A, Liposomal LICOCHALCONE A, LICOCHALCONE A NanoEmulsion, NanoActive LICOCHALCONE A
CAS:58749-22-7
MF:C21H22O4
MW:338.4
EINECS:635-678-2
Product Categories:The group of Liquorice;sy;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:58749-22-7.mol
LICOCHALCONE-A Structure
LICOCHALCONE-A Chemical Properties
Melting point 100°
Boiling point 532.6±50.0 °C(Predicted)
density 1.171±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMF:25.0(Max Conc. mg/mL);73.88(Max Conc. mM)
DMSO:37.67(Max Conc. mg/mL);111.31(Max Conc. mM)
Ethanol:43.5(Max Conc. mg/mL);128.54(Max Conc. mM)

pka7.82±0.15(Predicted)
form Yellow solid
color Yellow-orange
BRN 4534154
InChIKeyKAZSKMJFUPEHHW-DHZHZOJOSA-N
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
Safety Statements 36/37
WGK Germany 3
RTECS UB8755000
MSDS Information
LICOCHALCONE-A Usage And Synthesis
UsesLicochalcone A is an estrogenic flavonoid that induces apoptosis in multiple types of cancer cells. Licochalcone A applied to bone marrow mesenchymal stem cells (BMSC)-aggregate has strong osteogenetic differentiation thus providing a promising strategy in treating osteoporotic weight-bearing bone fractures with defects.
DefinitionChEBI: Licochalcone A is a member of chalcones.
General DescriptionAn estrogenic flavanoid with anti-tumor and anti-parasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation and enhances the effect of paclitaxel and vinblastine chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.
Biochem/physiol ActionsInhibits vegetative growth of spore-forming bacteria, B. subtilis and other food-contaminating microorganisms.
LICOCHALCONE-A Preparation Products And Raw materials
isoliquiritin apioside Cianidanol DihydrocurcuMin ISOLIQUIRITIN LICOCHALCONEC koumine LIQUIRITIN(SH) Phloretin LIQUIRITIGENIN CASTICIN LICOCHALCONE-A Swertiamarine Glabridin Isoliquiritigenin Licochalcone B Liguiritigenin-7-O-D-apiosyl-4’-O-D-glucoside 4,4'-DIHYDROXY-2-METHOXYCHALCONE 2,4,4'-TRIHYDROXY BENZALACETOPHENONE
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