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| | Pneumocandin B0 Basic information |
| | Pneumocandin B0 Chemical Properties |
| Melting point | >230°C (dec.) | | Boiling point | 1442.9±65.0 °C(Predicted) | | density | 1.41±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO (Slightly), Methanol (Sparingly) | | pka | 9.86±0.26(Predicted) | | form | Solid | | color | White to Off-White | | λmax | 276nm(MeOH)(lit.) |
| | Pneumocandin B0 Usage And Synthesis |
| Description | Pneumocandin B0 is an antifungal lipopeptide that acts by inhibiting the synthesis of β-(1,3)-D-glucan, a component of fungal cell walls (IC50s = 70 and 67 ng/ml for inhibiting glucan synthase in C. albicans and A. fumigatus, respectively). It can be used to synthesize the echinocandin caspofungin acetate . | | Uses | Pneumocandin B0 is the major analogue of a family of lipopeptides isolated from several species of several different genera, such as Cryptosporiopsis, Glarea and Pezicula. Pneumocandin B0 is a potent antifungal and acts by inhibition of the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi. | | Uses | Pneumocandin B0 is the major analogue of a family of lipopeptides isolated from some species of Cryptosporiopsis, Glarea and Pezicula. Pneumocandin B0 is a potent antifungal and acts by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi. | | Definition | ChEBI: An echinocandin initially isolated as a very minor bioactive fermentation product of Glarea lozoyensis (originally known as Zalerion arboricola). Subsequent random mutagenesis work and optimisation of the fermentation medium permi
ted the industrial production of pneumocandin B0, which is used as the starting point for the synthesis of the antifungal drug caspofungin. |
| | Pneumocandin B0 Preparation Products And Raw materials |
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