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| | GUVACINE HYDROCHLORIDE Basic information |
| Product Name: | GUVACINE HYDROCHLORIDE | | Synonyms: | GUVACINE HYDROCHLORIDE >96% \ GABA UPTAK;1,2,5,6-Tetrahydro-;1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Hydrochloride;3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride;Guvacine hydrochloride >=97% (NMR), solid;GUVACINE HYDROCHLORIDE;Norareca alkaloid hydrochloride | | CAS: | 6027-91-4 | | MF: | C6H10ClNO2 | | MW: | 163.6021 | | EINECS: | | | Product Categories: | GABA and Glycine Receptor ModulatorsNeurotransmitters;GABAergics;Ion Channels;Ligand-Gated Ion Channels;Others;Amines;Heterocycles;Intermediates & Fine Chemicals;Nicotine Derivatives;Pharmaceuticals | | Mol File: | 6027-91-4.mol |  |
| | GUVACINE HYDROCHLORIDE Chemical Properties |
| Melting point | 316 °C (decomp) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | H2O: soluble | | form | solid | | color | white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HazardClass | IRRITANT |
| | GUVACINE HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | Beige Solid | | Uses | Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders. | | Uses | Guvacine Hydrochloride is a GABA uptake inhibitor and it is used for the treatment of neurodegenerative diseases.
| | Biological Activity | Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). | | in vitro | Guvacine hydrochloride is a potent inhibitor of GABA transporter, dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Guvacine has low affinity at hBGT-1 (IC50 >1 mM). Guvacine hydrochloride is a potent inhibitor of GABA uptake, but does not inhibit sodium-independent GABA binding, and is weak or inactive as a GABA receptor agonist. Guvacine inhibits the uptake GABA and β-alanine with IC50s of 23 ± 2 μM, 66 ± 11 μM in the Cat spinal cord, and 8 ± 1 μM, 123 ± 28 μM in the rat cerebral cortex, respectively. |
| | GUVACINE HYDROCHLORIDE Preparation Products And Raw materials |
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