1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride

1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride Basic information
Product Name:1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride
Synonyms:1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride;Ethanone,1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino]-, hydrochloride (1:1);1-(3,4-Dihydroxyphenyl)-2-[(1-methylethyl)amino]ethanone hydrochloride;Isoprenaline impurity A;U 12844A;[2-(3,4-DIHYDROXYPHENYL)-2-OXOETHYL]-PROPAN-2-YLAZANIUM,CHLORIDE;3',4'-DIHYDROXY-2-(ISOPROPYLAMINO)-ACETOPHENONE HYDROCHLORIDE;Norepinephrine Impurity 10
CAS:16899-81-3
MF:C11H15NO3.ClH
MW:245.704
EINECS:240-943-7
Product Categories:
Mol File:16899-81-3.mol
1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride Structure
1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride Chemical Properties
Melting point 255-257℃
form neat
Safety Information
MSDS Information
1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride Usage And Synthesis
Uses1-(3,4-Dihydroxyphenyl)-2-[(1-methylethyl)amino]-ethanone is an impurity of Isoprenaline (I874200, HCl salt) which is non-selective beta-adrenergic agonist. Isoprenaline is used in the treatment of bradycardia.
PreparationObtained by condensation of a-chloro-3,4- dihydroxy-acetophenone with isopropylamine in isopropanol at 65–70°. The amino ketone which separated was treated with concentrated hydrochloric acid (54%), (46%).
1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride Preparation Products And Raw materials
Raw materials2-amino-1-(3,4-dihydroxyphenyl)ethan-1-one-->2-Chloropropane-->2-Chloro-3',4'-dihydroxyacetophenone-->Catechol-->Isopropylamine
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