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| | Meptazinol hydrochloride Basic information |
| | Meptazinol hydrochloride Chemical Properties |
| Melting point | 250-252°C | | storage temp. | Inert atmosphere,2-8°C | | solubility | H2O: >10mg/mL | | form | powder | | color | white to off-white | | Stability: | Hygroscopic | | InChIKey | MPJUSISYVXABBH-UHFFFAOYSA-N |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 1 | | RTECS | SL4250000 |
| | Meptazinol hydrochloride Usage And Synthesis |
| Description | Meptazinol hydrochloride is an injectable narcotic analgesic with antagonist
properties; it is similar in potency to meperidine. Meptazinol appears to have a
low propensity toward respiratory depression and other opiate-like side effects,
possibly due to selective interaction with the mu-1 receptor. Also somewhat
unique for an analgesic, it interacts with central cholinergic receptors. An oral
form of meptazinol is under development. | | Chemical Properties | White Solid | | Originator | Wyeth (United Kingdom) | | Uses | Analgesic;Opiate receptor agonist | | Uses | Mixed opioid agonist-antagonist. Analgesic (narcotic). | | Brand name | MEPTID | | Biological Activity | Centrally active opioid analgesic. Partial agonist at the μ 1 opioid receptor. Also shown to inhibit acetylcholinesterase. | | Biochem/physiol Actions | Meptazinol entered the human pharmaceutical market as a racemic mixture in the 1980s for use as an analgesic. Its pharmacology is not completely understood; however, its analgesic properties are mostly due to its partial agonism at the mu1 opioid receptor. Due to its partial agonism, Meptazinol antagonizes morphine dependence in vivo. Its advantage over other opiates is its reduced capacity to cause addition and respiratory depression, also due to its intrinsic activity as a partial agonist. Meptazinol has been found to have additional activity as an acetylcholinesterase (AChE) inhibitor, particularly in its (-) enantiomeric form, which may partially explain its analgesic properties. AChE inhibitors are used to treat Alzheimer′s disease, providing additional interest in this compound. |
| | Meptazinol hydrochloride Preparation Products And Raw materials |
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