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Ethyl N-Boc-piperidine-4-carboxylate

Ethyl N-Boc-piperidine-4-carboxylate Basic information
Product Name:Ethyl N-Boc-piperidine-4-carboxylate
Synonyms:N-BOC-4-CARBETHOXY PIPERIDINE;PIPERIDINE-1,4-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 4-ETHYL ESTER;1-BOC-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER;1-TERT-BUTYL 4-ETHYL 1,4-PIPERIDINEDICARBOXYLATE;1-TERT-BUTYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE;1-(TERT-BUTYL) 4-ETHYL TETRAHYDRO-1,4(2H)-PYRIDINEDICARBOXYLATE;Ethyl N-Boc-piperidine-4-carboxylate;N-BOC-4-piperidine forMic acid ethyl ester
CAS:142851-03-4
MF:C13H23NO4
MW:257.33
EINECS:
Product Categories:Esters;Pyrans, Piperidines &Piperazines;Amino Acids and Derivatives;Heterocycles;Pyrans, Piperidines & Piperazines
Mol File:142851-03-4.mol
Ethyl N-Boc-piperidine-4-carboxylate Structure
Ethyl N-Boc-piperidine-4-carboxylate Chemical Properties
Boiling point 120-135 °C/0.5 mmHg
density 1.046 g/mL at 25 °C
refractive index n20/D 1.458
Fp >230 °F
storage temp. Inert atmosphere,2-8°C
solubility Chloroform, Ethyl Acetate
pka-2.23±0.40(Predicted)
form Liquid
color Clear colorless to pale yellow
InChIKeyMYHJCTUTPIKNAT-UHFFFAOYSA-N
CAS DataBase Reference142851-03-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22-37/38-41
Safety Statements 26-39
WGK Germany 3
HazardClass IRRITANT
HS Code 29333990
MSDS Information
ProviderLanguage
SigmaAldrich English
Ethyl N-Boc-piperidine-4-carboxylate Usage And Synthesis
Chemical PropertiesLiquid
UsesEthyl N-Boc-piperidine-4-carboxylate is used as a reagent to synthesize 3-amino-1-(5-indanyloxy)-2-propanol derivatives as sodium channel blockers to treat stroke patients. Ethyl N-Boc-piperidine-4-carboxylate is also used as a reagent to prepare inhibitors of tumour necrosis factor alpha-converting enzyme.
UsesSubstrate used in a palladium-catalyzed α-arylation of esters with heterocyclic bromides and chlorides leading to, for example, 4-pyridylpiperidinyl esters.
Ethyl N-Boc-piperidine-4-carboxylate Preparation Products And Raw materials
Preparation Products2-Oxa-8-azaspiro[4.5]decane-->1-Boc-4-[methoxy(methyl)carbamoyl]piperidine-->1,4-Piperidinedicarboxylic acid, 4-(cyanomethyl)-, 1-(1,1-dimethylethyl) 4-ethyl ester-->Ethyl 4-Ethyl-4-piperidinecarboxylate Hydrochloride-->ETHYL N-BOC-4-(4-FLUOROBENZYL)PIPERIDINE-4-CARBOXYLATE-->ethyl 4-methanesulfonylpiperidine-4-carboxylate hydrochloride-->tert-butyl 4-[3-(4-chlorophenyl)-1H-1,2,4-triazol-5-yl]piperidine-1-carboxylate-->7-Boc-1-oxo-3-phenyl-2,7-diaza-spiro[3.5]nonane-->tert-butyl 2-benzyl-1-oxo-2,7-diazaspiro[3.5]nonane-7-carboxylate
Trinexapac-ethyl Ethanol Cyclohexanecarboxylic acid ethyl ester OXALIC ACID Ethyl formate Piperidine Urethane Buprofezin Ethylparaben Ethyl chloroformate ISOXADIFEN-ETHYL 2-Ethoxyethanol Diethyl ether Ethyl 4-piperidinecarboxylate Ethyl acetate Isonipecotic acid Ethyl nipecotate Ethyl cyanoformate
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