4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE

4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE Basic information

Product Name:	4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE
Synonyms:	4-methylumberiferryl-N-acetyl-beta-D-glucosaminide.2H2O;2-Oxo-4-methyl-2H-1-benzopyran-7-yl 2-(acetylamino)-2-deoxy-β-D-glucopyranoside;4-Methyl-2-oxo-2H-1-benzopyran-7-yl 2-(acetylamino)-2-deoxy-β-D-glucopyranoside;4-Methylumbelliferyl-β-N-acetylglucosamine;4-Methylumbelliferyl-β-N-acetylglucosaminide;4-MU-GlcNAc;7-[[2-(Acetylamino)-2-deoxy-β-D-glucopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one;4-Methylumbelliferyl-N-acetyl-beta-D-glucosaminide,99%
CAS:	37067-30-4
MF:	C18H21NO8
MW:	379.37
EINECS:	253-333-0
Product Categories:	Substrates;Sugars, Carbohydrates & Glucosides;Carbohydrates & Derivatives;Fluorescent Labels & Indicators;substrate
Mol File:	37067-30-4.mol

4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE Chemical Properties

Melting point	208-210 °C
Boiling point	507.24°C (rough estimate)
density	1.4163 (rough estimate)
refractive index	1.5740 (estimate)
storage temp.	-20°C
solubility	DMF: 20 mg/mL, clear, colorless
pka	12.87±0.70(Predicted)
form	Crystalline solid
color	White to Off-White
λmax	360nm(Phosphate buffer sol.)(lit.)
BRN	1693397
Stability:	Light Sensitive - Protect from Light
LogP	0.340 (est)
CAS DataBase Reference	37067-30-4(CAS DataBase Reference)
EPA Substance Registry System	2H-1-Benzopyran-2-one, 7-[[2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl]oxy]-4-methyl- (37067-30-4)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE Usage And Synthesis

Chemical Properties	4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE is White Crystalline Solid
Uses	4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE is used for the assay of b-Acetylglucosaminidase. A fluorogenic substrate used for the diagnosis of GM2 gangliosidoses in leukocytes. Genetic defects in human b-hexosaminidase isozy mes (Hex A & Hex B) result in various clinical and biochemical types of GM2 gangliosidosis. They include Tay Sachs disease, Sandhoff disease and other forms. Fluorescence: max. Abs. l = 325nm, max. Em. l = 378nm
Uses	4-Methylumbelliferyl N-acetyl-β-D-glucosaminide has been used as a substrate for assaying β-N-acetylglucosaminidase (NAGase) from soil samples chitinase from Fusarium oxysporum using fluorimetric assay β-N-acetylhexosaminidases from Arabidopsis thaliana roots and leaves samples
General Description	4-Methylumbelliferyl N-acetyl-β-D-glucosaminide (4-MUF-NAG) contains chitin monomer, N-acetyl-D-glucosamine (NAG) and a 4-methylumbelliferone (7-hydroxy-4-methylcoumarin) (4-MUF) moiety.
Biochem/physiol Actions	4-Methylumbelliferyl N-acetyl-β-D-glucosaminide (4-MUF-NAG) is a synthetic fluorogenic substrate for N-acetyl-β-D-glucosaminidase (NAGase). The enzyme functionality is assessed by its ability to hydrolyze the N-acetyl-D-glucosamine (NAG) residue in 4-MUF-NAG. 4-MUF-NAG is also a substrate for Chitinase and N-acetylhexosaminidase.

4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE Preparation Products And Raw materials

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