ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyrimidines Chloropyrimidine 5-Bromo-2-chloropyrimidine

5-Bromo-2-chloropyrimidine

5-Bromo-2-chloropyrimidine Basic information
Product Name:5-Bromo-2-chloropyrimidine
Synonyms:PYRIMIDINE, 5-BROMO-2-CHLORO-;2-chloro-5-broMopyriMidine(5-broMo-2-chloropyriMidine);2-chloro -5-broMo - uracil;5 - broMine - 2 - chloro pyriMidine;5-methyl-4,5-dihydrothiazol-2-amine;Macitentan Intermediate 5;Macitentan Impurity 27;5-BROMO-2-CHLOROPYRIMIDINE
CAS:32779-36-5
MF:C4H2BrClN2
MW:193.43
EINECS:629-214-8
Product Categories:Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Pyrimidine Series;Halides;Pyrazines, Pyrimidines & Pyridazines;Pyrimidine;Heterocycles;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Variety of halogenated heterocyclic series;Halogenated;Organohalides;Building Blocks;C4 to C5;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyrimidine series;Pharmaceutical intermediates;Thiophenes;bc0001
Mol File:32779-36-5.mol
5-Bromo-2-chloropyrimidine Structure
5-Bromo-2-chloropyrimidine Chemical Properties
Melting point 73-79 °C (lit.)
Boiling point 95°C 15mm
density 1.859±0.06 g/cm3(Predicted)
Fp 95°C/15mm
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
pka-2.84±0.22(Predicted)
form Crystalline Powder
color Off-white to beige
Water Solubility insoluble
BRN 507955
Stability:Hygroscopic
InChIKeyXPGIBDJXEVAVTO-UHFFFAOYSA-N
CAS DataBase Reference32779-36-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36/39-37/39-36
RIDADR UN 3335
WGK Germany 3
HazardClass IRRITANT
HS Code 29335990
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
5-Bromo-2-chloropyrimidine Usage And Synthesis
Chemical PropertiesOff-white to beige crystalline powder
Uses5-Bromo-2-chloropyrimidine is a intermediate in the synthesis of pharmaceutical goods such as inhibitors.
UsesIt is applied as a pharmaceutical intermediate, in the synthesis of pharmaceutical goods such as inhibitors. It is also employed in the cross-coupling reactions of indium organometallics with 2,5-dihalopyrimidines.
5-Bromo-2-chloropyrimidine Preparation Products And Raw materials
Preparation Products5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID-->5-BROMO-2-(DIMETHYLAMINO)PYRIMIDINE-->5-BROMO-2-(METHYLAMINO)PYRIMIDINE-->5-Bromopyrimidine-2-carbonitrile-->5-BROMO-2-(PYRROLIDIN-1-YL)PYRIMIDINE-->2-CHLOROPYRIMIDINE-5-BORONIC ACID-->5-BROMO-2-ETHOXY-PYRIMIDINE-->(5-BROMO-PYRIMIDIN-2-YL)-DIETHYL-AMINE-->2-CHLORO-5-PHENYL-PYRIMIDINE-->2-Chloropyrimidine-5-carbaldehyde-->5-Bromo-2-methoxypyrimidine-->Tert-Butyl Methyl 2-(5-Bromopyrimidin-2-Yl)Malonate-->N-(5-BroMopyriMidin-2-yl)-N-MethylacetaMide
2-(5-BROMO-2-CHLOROPYRIMIDIN-4-YL)-2-(1-METHYL-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-2-YLIDEN)ACETONITRILE 4-AMINO-5-BROMO-2-CHLOROPYRIMIDINE, 95+%,4-AMINO-5-BROMO-2-CHLOROPYRIMIDINE 5-Bromo-2,4-dichloropyrimidine 1-Bromo-3-chloro-5,5-dimethylhydantoin 3-Bromoanisole 4-BENZYLOXY-5-BROMO-2-CHLOROPYRIMIDINE 5-Bromo-2-chloropyrimidine RARECHEM AL BW 1864 5-BROMO-2-CHLORO-4-(METHYLTHIO)PYRIMIDINE 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE 2-Chloropyrimidine 5-Bromo-2-iodopyrimidine Bromochloromethane Bromine Chlorobromoisocyanurate 5-Bromopyrimidine RARECHEM AL BO 2081 4-(AMINOACETALDEHYDE DIMETHYL ACETAL)-5-BROMO-2-CHLOROPYRIMIDINE
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